ID   8E5(CEM)
AC   CVCL_3484
SY   8E5/LAV; 8E5
DR   CLO; CLO_0001521
DR   ATCC; CRL-8993
DR   BioSample; SAMN03471213
DR   cancercelllines; CVCL_3484
DR   HIVReagentProgram; ARP-95
DR   Wikidata; Q54605508
RX   Patent=US4752565;
RX   PubMed=3014036;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8993.
CC   Population: Caucasian.
CC   Virology: HIV-1 producing cell line.
CC   Sequence variation: Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
ST   Source(s): ATCC
ST   Amelogenin: X
ST   CSF1PO: 9,11
ST   D13S317: 12,13
ST   D16S539: 10,13
ST   D5S818: 12
ST   D7S820: 9,13
ST   TH01: 6,7
ST   TPOX: 8
ST   vWA: 17,20
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_6244 ! CEM A3.01
SX   Female
AG   3Y11M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 21
//
RX   Patent=US4752565;
RA   Folks T.M., Powell D.M., Martin M.A.;
RT   "Cell line producing AIDS viral antigens without producing infectious
RT   virus particles.";
RL   Patent number US4752565, 21-Jun-1988.
//
RX   PubMed=3014036; DOI=10.1084/jem.164.1.280;
RA   Folks T.M., Powell D., Lightfoote M., Koenig S., Fauci A.S., Benn S.,
RA   Rabson A., Daugherty D., Gendelman H.E., Hoggan M.D., Venkatesan S.,
RA   Martin M.A.;
RT   "Biological and biochemical characterization of a cloned Leu-3- cell
RT   surviving infection with the acquired immune deficiency syndrome
RT   retrovirus.";
RL   J. Exp. Med. 164:280-290(1986).
//