| Cell line name |
WiDr/R |
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| Accession |
CVCL_2N03 |
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| Resource Identification Initiative |
To cite this cell line use: WiDr/R (RRID:CVCL_2N03) |
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| Comments |
Problematic cell line: Contaminated. Parent cell line (WiDr) had been shown to be a HT-29 derivative.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:50729; Mitoxantrone.
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
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| Sequence variations |
- Mutation; HGNC; 583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Colon adenocarcinoma (NCIt: C4349) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_2760 (WiDr) |
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| Sex of cell |
Female |
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| Age at sampling |
44Y |
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| Category |
Cancer cell line |
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| Publications | CLPUB00271
Wallace R.E., Lindh D., Durr F.E.
Studies on the development of resistance to mitoxantrone in human colon carcinoma cells in vitro.
Proc. Am. Assoc. Cancer Res. 23:767-767(1982) PubMed=2894893
Dalton W.S., Cress A.E., Alberts D.S., Trent J.M.
Cytogenetic and phenotypic analysis of a human colon carcinoma cell line resistant to mitoxantrone.
Cancer Res. 48:1882-1888(1988) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_2N03
|
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| Encyclopedic resources |
Wikidata; Q54994057
|
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| Entry history |
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| Entry creation | 14-Dec-2015 |
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| Last entry update | 05-Oct-2023 |
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| Version number | 18 |
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