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Cellosaurus VP229 (CVCL_2754)

[Text version]
Cell line name VP229
Synonyms VP 229; BrCL18
Accession CVCL_2754
Resource Identification Initiative To cite this cell line use: VP229 (RRID:CVCL_2754)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Omics: Deep exome analysis.
Omics: miRNA expression profiling.
Sequence variations
  • Mutation; HGNC; 3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Hemizygous (PubMed=10700188).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Unspecified (PubMed=10700188; DepMap).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_2755 ! VP267
Sex of cell Female
Age at sampling 47Y
Category Cancer cell line
STR profile Source(s): DepMap; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10
D2S133818,25
D3S135816,18
D5S81811
D7S82010,12
D8S117910,13
D13S31711,13
D16S53911,12
D18S5116
D19S43313
D21S1129
FGA18
Penta D10
Penta E13,17
TH017
TPOX8
vWA17

Run an STR similarity search on this cell line
Web pages https://www.cellosaurus.org/pawefish/BreastCellLineDescriptions/VP229.html
Publications

PubMed=8877005; DOI=10.1007/BF01806153
McCallum H.M., Lowther G.W.
Long-term culture of primary breast cancer in defined medium.
Breast Cancer Res. Treat. 39:247-259(1996)

PubMed=10700188; DOI=10.1038/73536
Gayther S.A., Batley S.J., Linger L., Bannister A.J., Thorpe K., Chin S.-F., Daigo Y., Russell P., Wilson A., Sowter H.M., Delhanty J.D.A., Ponder B.A.J., Kouzarides T., Caldas C.
Mutations truncating the EP300 acetylase in human cancers.
Nat. Genet. 24:300-303(2000)

PubMed=11044355; DOI=10.1054/bjoc.2000.1458
Davidson J.M., Gorringe K.L., Chin S.-F., Orsetti B., Besret C., Courtay-Cahen C., Roberts I., Theillet C., Caldas C., Edwards P.A.W.
Molecular cytogenetic analysis of breast cancer cell lines.
Br. J. Cancer 83:1309-1317(2000)

PubMed=12800145; DOI=10.1002/gcc.10218
Adelaide J., Huang H.-E., Murati A., Alsop A.E., Orsetti B., Mozziconacci M.-J., Popovici C., Ginestier C., Letessier A., Basset C., Courtay-Cahen C., Jacquemier J., Theillet C., Birnbaum D., Edwards P.A.W., Chaffanet M.
A recurrent chromosome translocation breakpoint in breast and pancreatic cancer cell lines targets the neuregulin/NRG1 gene.
Genes Chromosomes Cancer 37:333-345(2003)

PubMed=15677628; DOI=10.1093/carcin/bgi032
Gorringe K.L., Chin S.-F., Pharoah P.D.P., Staines J.M., Oliveira C., Edwards P.A.W., Caldas C.
Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer.
Carcinogenesis 26:923-930(2005)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

Cross-references
Cell line collections (Providers) ECACC; 05092804
Cell line databases/resources cancercelllines; CVCL_2754
Cell_Model_Passport; SIDM01826
DepMap; ACH-001419
Biological sample resources BioSample; SAMN03472874
Encyclopedic resources Wikidata; Q54993312
Gene expression databases GEO; GSM115113
GEO; GSM217608
GEO; GSM219888
Polymorphism and mutation databases Cosmic; 1523834
Progenetix; CVCL_2754
Sequence databases EGA; EGAS00001002554
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number23