ID   VP229
AC   CVCL_2754
SY   VP 229; BrCL18
DR   BioSample; SAMN03472874
DR   cancercelllines; CVCL_2754
DR   Cell_Model_Passport; SIDM01826
DR   Cosmic; 1523834
DR   DepMap; ACH-001419
DR   ECACC; 05092804
DR   EGA; EGAS00001002554
DR   GEO; GSM115113
DR   GEO; GSM217608
DR   GEO; GSM219888
DR   Progenetix; CVCL_2754
DR   Wikidata; Q54993312
RX   PubMed=8877005;
RX   PubMed=10700188;
RX   PubMed=11044355;
RX   PubMed=12800145;
RX   PubMed=15677628;
RX   PubMed=25877200;
WW   https://www.cellosaurus.org/pawefish/BreastCellLineDescriptions/VP229.html
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Sequence variation: Mutation; HGNC; 3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Hemizygous (PubMed=10700188).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Unspecified (PubMed=10700188; DepMap).
CC   Omics: Deep exome analysis.
CC   Omics: miRNA expression profiling.
ST   Source(s): DepMap; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 11,13
ST   D16S539: 11,12
ST   D18S51: 16
ST   D19S433: 13
ST   D21S11: 29
ST   D2S1338: 18,25
ST   D3S1358: 16,18
ST   D5S818: 11
ST   D7S820: 10,12
ST   D8S1179: 10,13
ST   FGA: 18
ST   Penta D: 10
ST   Penta E: 13,17
ST   TH01: 7
ST   TPOX: 8
ST   vWA: 17
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_2755 ! VP267
SX   Female
AG   47Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 23
//
RX   PubMed=8877005; DOI=10.1007/BF01806153;
RA   McCallum H.M., Lowther G.W.;
RT   "Long-term culture of primary breast cancer in defined medium.";
RL   Breast Cancer Res. Treat. 39:247-259(1996).
//
RX   PubMed=10700188; DOI=10.1038/73536;
RA   Gayther S.A., Batley S.J., Linger L., Bannister A.J., Thorpe K.,
RA   Chin S.-F., Daigo Y., Russell P., Wilson A., Sowter H.M.,
RA   Delhanty J.D.A., Ponder B.A.J., Kouzarides T., Caldas C.;
RT   "Mutations truncating the EP300 acetylase in human cancers.";
RL   Nat. Genet. 24:300-303(2000).
//
RX   PubMed=11044355; DOI=10.1054/bjoc.2000.1458;
RA   Davidson J.M., Gorringe K.L., Chin S.-F., Orsetti B., Besret C.,
RA   Courtay-Cahen C., Roberts I., Theillet C., Caldas C., Edwards P.A.W.;
RT   "Molecular cytogenetic analysis of breast cancer cell lines.";
RL   Br. J. Cancer 83:1309-1317(2000).
//
RX   PubMed=12800145; DOI=10.1002/gcc.10218;
RA   Adelaide J., Huang H.-E., Murati A., Alsop A.E., Orsetti B.,
RA   Mozziconacci M.-J., Popovici C., Ginestier C., Letessier A.,
RA   Basset C., Courtay-Cahen C., Jacquemier J., Theillet C., Birnbaum D.,
RA   Edwards P.A.W., Chaffanet M.;
RT   "A recurrent chromosome translocation breakpoint in breast and
RT   pancreatic cancer cell lines targets the neuregulin/NRG1 gene.";
RL   Genes Chromosomes Cancer 37:333-345(2003).
//
RX   PubMed=15677628; DOI=10.1093/carcin/bgi032;
RA   Gorringe K.L., Chin S.-F., Pharoah P.D.P., Staines J.M., Oliveira C.,
RA   Edwards P.A.W., Caldas C.;
RT   "Evidence that both genetic instability and selection contribute to
RT   the accumulation of chromosome alterations in cancer.";
RL   Carcinogenesis 26:923-930(2005).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//