Due to maintenance work, this service will be unavailable from
Mon Nov 11 17:30 until
Tue Nov 12 09:00
CET.
Apologies for the inconvenience.
| Cell line name |
J45.01 |
|---|
| Accession |
CVCL_2530 |
|---|
| Resource Identification Initiative |
To cite this cell line use: J45.01 (RRID:CVCL_2530) |
|---|
| Comments |
Population: Caucasian.
Characteristics: CD45-deficient.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084. |
|---|
| Sequence variations |
- Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11491; SYK; Simple; p.Met34Hisfs*3 (c.98_99insG); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
|
|---|
| Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_0367 (Jurkat E6.1) |
|---|
| Sex of cell |
Male |
|---|
| Age at sampling |
14Y |
|---|
| Category |
Cancer cell line |
|---|
| STR profile |
Source(s): ATCC=CRL-1990; PubMed=25877200
Markers:| Amelogenin | X,Y |
| CSF1PO | 11,12 |
| D2S1338 | 19,23 |
| D3S1358 | 14,17 |
| D5S818 | 9 |
| D7S820 | 8,9.3,10.3 |
| D8S1179 | 14,15 |
| D13S317 | 8,11,12 |
| D16S539 | 11 |
| D18S51 | 13,21,22 (PubMed=25877200)
13,22 (ATCC=CRL-1990) |
| D19S433 | 14,15.2 |
| D21S11 | 31.2,33.2,34.2 |
| FGA | 20,21 |
| Penta D | 11,13 |
| Penta E | 10,12 |
| TH01 | 6,9.3 |
| TPOX | 8,10 |
| vWA | 18 |
Run an STR similarity search on this cell line |
|---|
| Publications | PubMed=1672451; DOI=10.1073/pnas.88.6.2037; PMCID=PMC51163
Koretzky G.A., Picus J., Schultz T., Weiss A.
Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production.
Proc. Natl. Acad. Sci. U.S.A. 88:2037-2041(1991) PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015) |
|---|
| Cross-references |
|---|
| Cell line collections (Providers) |
ATCC; CRL-1990
BCRC; 60255
ECACC; 93031145
|
|---|
| Cell line databases/resources |
CLO; CLO_0006998
CLDB; cl2921
cancercelllines; CVCL_2530
LINCS_LDP; LCL-1029
|
|---|
| Biological sample resources |
BioSample; SAMN03470881
|
|---|
| Encyclopedic resources |
Wikidata; Q54898471
|
|---|
| Entry history |
|---|
| Entry creation | 04-Apr-2012 |
|---|
| Last entry update | 02-May-2024 |
|---|
| Version number | 29 |
|---|
