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Cellosaurus Ej138 (CVCL_2443)

[Text version]
Cell line name Ej138
Synonyms EJ138; EJ 138; MGH-U1; MGHU1; MGH-UI; MGH-U1 (EJ); EJ
Accession CVCL_2443
Resource Identification Initiative To cite this cell line use: Ej138 (RRID:CVCL_2443)
Comments Problematic cell line: Contaminated. Shown to be a T24 derivative (PubMed=3708594; PubMed=6823318; PubMed=20143388).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00080.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00195.
Population: Caucasian; Swedish.
Doubling time: 20 hours (PubMed=3708594).
Omics: SNP array analysis.
Omics: Transcriptome analysis by ESTs sequencing.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Sequence variations
  • Mutation; HGNC; 5173; HRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012600; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr126Ter (c.378C>G); ClinVar=VCV000578988; Zygosity=Homozygous (from parent cell line).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0554 (T24)
Sex of cell Female
Age at sampling 82Y
Category Cancer cell line
STR profile Source(s): PubMed=11416159


Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx

PubMed=864752; DOI=10.1093/jnci/58.6.1743
Marshall C.J., Franks L.M., Carbonell A.W.
Markers of neoplastic transformation in epithelial cell lines derived from human carcinomas.
J. Natl. Cancer Inst. 58:1743-1751(1977)

PubMed=870558; DOI=10.1177/25.4.870558
Benham F.J., Cottell D.C., Franks L.M., Wilson P.D.
Alkaline phosphatase activity in human bladder tumor cell lines.
J. Histochem. Cytochem. 25:266-274(1977)

PubMed=651066; DOI=10.5980/jpnjurol1928.69.1_40
Kato T., Ishikawa K., Nemoto R.
Morphologic characterization of two established cell lines, T24 and MGH-U1, derived from human bladder carcinoma.
Nihon Hinyokika Gakkai Zasshi 69:40-46(1978)

PubMed=663932; DOI=10.1620/tjem.124.33
Kato T., Ishikawa K., Nemoto R., Senoo A., Amano Y.
Morphological characterization of two established cell lines, T24 and MGH-U1, derived from human urinary bladder carcinoma.
Tohoku J. Exp. Med. 124:339-349(1978)

Williams R.D.
Human urologic cancer cell lines.
Invest. Urol. 17:359-363(1980)

PubMed=7185004; DOI=10.2302/kjm.31.127
Tachibana M.
Studies on cellular adhesiveness in five different culture cell lines derived from carcinoma of the urinary bladder.
Keio J. Med. 31:127-148(1982)

PubMed=6823318; DOI=10.1038/301429a0
O'Toole C.M., Povey S., Hepburn P.J., Franks L.M.
Identity of some human bladder cancer cell lines.
Nature 301:429-430(1983)

PubMed=6826254; DOI=10.1002/ijc.2910310308
Paulie S., Hansson Y., Lundblad M.-L., Perlmann P.
Lectins as probes for identification of tumor-associated antigens on urothelial and colonic carcinoma cell lines.
Int. J. Cancer 31:297-303(1983)

Lin C.-W., Lin J.C., Prout G.R. Jr.
Establishment and characterization of four human bladder tumor cell lines and sublines with different degrees of malignancy.
Cancer Res. 45:5070-5079(1985)

Masters J.R.W., Hepburn P.J., Walker L., Highman W.J., Trejdosiewicz L.K., Povey S., Parkar M., Hill B.T., Riddle P.N., Franks L.M.
Tissue culture model of transitional cell carcinoma: characterization of twenty-two human urothelial cell lines.
Cancer Res. 46:3630-3636(1986)

PubMed=2903891; DOI=10.1080/09553008814552341
Peacock J.H., Cassoni A.M., McMillan T.J., Steel G.G.
Radiosensitive human tumour cell lines may not be recovery deficient.
Int. J. Radiat. Biol. 54:945-953(1988)

PubMed=11416159; DOI=10.1073/pnas.121616198
Masters J.R.W., Thomson J.A., Daly-Burns B., Reid Y.A., Dirks W.G., Packer P., Toji L.H., Ohno T., Tanabe H., Arlett C.F., Kelland L.R., Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=23401075; DOI=10.1002/path.4176
Guo Y.-N., Chekaluk Y., Zhang J.-M., Du J.-Y., Gray N.S., Wu C.-L., Kwiatkowski D.J.
TSC1 involvement in bladder cancer: diverse effects and therapeutic implications.
J. Pathol. 230:17-27(2013)

PubMed=25336970; DOI=10.2147/OTT.S69239
Yang P.-S., Hsu Y.-C., Lin Y.-H., Hou C.-P., Chen C.-L., Chang P.-L., Juang H.-H., Tsui K.-H.
The expression sequence tag is an effective method for screening DNA segments that predict urinary bladder transitional cell carcinoma prognosis.
Onco Targets Ther. 7:1777-1781(2014)

Cell line collections (Providers) ECACC; 85061108
NCBI_Iran; C429
Cell line databases/resources CLO; CLO_0002905
CLO; CLO_0002906
CLDB; cl1152
CLDB; cl1154
cancercelllines; CVCL_2443
Anatomy/cell type resources BTO; BTO:0003553
Biological sample resources BioSample; SAMN03151939
BioSample; SAMN03151949
Chemistry resources ChEMBL-Cells; CHEMBL3307583
ChEMBL-Targets; CHEMBL614292
PubChem_Cell_line; CVCL_2443
Encyclopedic resources Wikidata; Q54832176
Gene expression databases GEO; GSM827443
GEO; GSM1374473
Polymorphism and mutation databases Cosmic; 760480
Cosmic; 925828
Cosmic; 1093986
Cosmic; 1927289
Progenetix; CVCL_2443
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number33