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Cellosaurus UPCI-SCC-154 (CVCL_2230)

[Text version]
Cell line name UPCI-SCC-154
Synonyms UPCI:SCC154; UPCISCC154; SCC154
Accession CVCL_2230
Resource Identification Initiative To cite this cell line use: UPCI-SCC-154 (RRID:CVCL_2230)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: MD Anderson Cell Lines Project.
Population: Caucasian.
Doubling time: 3.8 days (PubMed=29156801); ~50-60 hours (DSMZ=ACC-669).
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Omics: Deep exome analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Oral cavity, tongue; UBERON=UBERON_0001723.
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Squamous cell carcinoma of the oral tongue (ORDO: Orphanet_457252)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): ATCC; DepMap; DSMZ; PubMed=29156801; PubMed=33802339

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133825
D3S135815,16 (DSMZ)
16 (DepMap; PubMed=33802339)
D5S81811,12
D7S8209,10
D8S117912
D13S3179,12
D16S53913
D18S5115
D19S43315.2,16 (PubMed=33802339)
16 (DSMZ)
D21S1128,29
FGA20,24
Penta D11,13
Penta E5,14
TH017
TPOX8,9
vWA17

Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/
Publications

PubMed=17112776; DOI=10.1016/j.oraloncology.2006.09.001
White J.S., Weissfeld J.L., Ragin C.C.R., Rossie K.M., Martin C.L., Shuster M., Ishwad C.S., Law J.C., Myers E.N., Johnson J.T., Gollin S.M.
The influence of clinical and demographic risk factors on the establishment of head and neck squamous cell carcinoma cell lines.
Oral Oncol. 43:701-712(2007)

PubMed=24403267; DOI=10.1002/cam4.151
Kawakami H., Okamoto I., Terao K., Sakai K., Suzuki M., Ueda S., Tanaka K., Kuwata K., Morita Y., Ono K., Nishio K., Nishimura Y., Doi K., Nakagawa K.
Human papillomavirus DNA and p16 expression in Japanese patients with oropharyngeal squamous cell carcinoma.
Cancer Med. 2:933-941(2013)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=28236344; DOI=10.1002/hed.24729
Walline H.M., Goudsmit C.M., McHugh J.B., Tang A.L., Owen J.H., Teh B.T., McKean E.L., Glover T.W., Graham M.P., Prince M.E.P., Chepeha D.B., Chinn S.B., Ferris R.L., Gollin S.M., Hoffmann T.K., Bier H., Brakenhoff R.H., Bradford C.R., Carey T.E.
Integration of high-risk human papillomavirus into cellular cancer-related genes in head and neck cancer cell lines.
Head Neck 39:840-852(2017)

PubMed=28476783; DOI=10.21873/anticanres.11555
Hagemann J., Jacobi C., Hahn M., Schmid V., Welz C., Schwenk-Zieger S., Stauber R.H., Baumeister P., Becker S.
Spheroid-based 3D cell cultures enable personalized therapy testing and drug discovery in head and neck cancer.
Anticancer Res. 37:2201-2210(2017)

PubMed=29156801; DOI=10.18632/oncotarget.21174
Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y., Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J., Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

PubMed=33802339; DOI=10.3390/cancers13051069
Gottgens E.-L., Ansems M., Leenders W.P.J., Bussink J., Span P.N.
Genotyping and characterization of HPV status, hypoxia, and radiosensitivity in 22 head and neck cancer cell lines.
Cancers (Basel) 13:1069.1-1069.12(2021)

Cross-references
Cell line collections (Providers) ATCC; CRL-3241
DSMZ; ACC-669
IZSLER; BS TCL 245
Cell line databases/resources DepMap; ACH-001229
DSMZCellDive; ACC-669
Biological sample resources BioSample; SAMN03473423
Encyclopedic resources Wikidata; Q54991687
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number23