ID   UPCI-SCC-154
AC   CVCL_2230
SY   UPCI:SCC154; UPCISCC154; SCC154
DR   ATCC; CRL-3241
DR   BioSample; SAMN03473423
DR   DepMap; ACH-001229
DR   DSMZ; ACC-669
DR   DSMZCellDive; ACC-669
DR   IZSLER; BS TCL 245
DR   Wikidata; Q54991687
RX   PubMed=17112776;
RX   PubMed=24403267;
RX   PubMed=28196595;
RX   PubMed=28236344;
RX   PubMed=28476783;
RX   PubMed=29156801;
RX   PubMed=33802339;
WW   https://tcpaportal.org/mclp/
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: MD Anderson Cell Lines Project.
CC   Population: Caucasian.
CC   Doubling time: 3.8 days (PubMed=29156801); ~50-60 hours (DSMZ=ACC-669).
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Omics: Deep exome analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Oral cavity, tongue; UBERON=UBERON_0001723.
ST   Source(s): ATCC=CRL-3241; DepMap=ACH-001229; DSMZ=ACC-669; PubMed=29156801; PubMed=33802339
ST   Amelogenin: X,Y
ST   CSF1PO: 10,12
ST   D13S317: 9,12
ST   D16S539: 13
ST   D18S51: 15
ST   D19S433: 15.2,16 (PubMed=33802339)
ST   D19S433: 16 (DSMZ=ACC-669)
ST   D21S11: 28,29
ST   D2S1338: 25
ST   D3S1358: 15,16 (DSMZ=ACC-669)
ST   D3S1358: 16 (DepMap=ACH-001229; PubMed=33802339)
ST   D5S818: 11,12
ST   D7S820: 9,10
ST   D8S1179: 12
ST   FGA: 20,24
ST   Penta D: 11,13
ST   Penta E: 5,14
ST   TH01: 7
ST   TPOX: 8,9
ST   vWA: 17
DI   NCIt; C4648; Tongue squamous cell carcinoma
DI   ORDO; Orphanet_457252; Squamous cell carcinoma of the oral tongue
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   54Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 24
//
RX   PubMed=17112776; DOI=10.1016/j.oraloncology.2006.09.001;
RA   White J.S., Weissfeld J.L., Ragin C.C.R., Rossie K.M., Martin C.L.,
RA   Shuster M., Ishwad C.S., Law J.C., Myers E.N., Johnson J.T.,
RA   Gollin S.M.;
RT   "The influence of clinical and demographic risk factors on the
RT   establishment of head and neck squamous cell carcinoma cell lines.";
RL   Oral Oncol. 43:701-712(2007).
//
RX   PubMed=24403267; DOI=10.1002/cam4.151;
RA   Kawakami H., Okamoto I., Terao K., Sakai K., Suzuki M., Ueda S.,
RA   Tanaka K., Kuwata K., Morita Y., Ono K., Nishio K., Nishimura Y.,
RA   Doi K., Nakagawa K.;
RT   "Human papillomavirus DNA and p16 expression in Japanese patients with
RT   oropharyngeal squamous cell carcinoma.";
RL   Cancer Med. 2:933-941(2013).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005;
RA   Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P.,
RA   Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L.,
RA   Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D.,
RA   Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B.,
RA   Liang H.;
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=28236344; DOI=10.1002/hed.24729;
RA   Walline H.M., Goudsmit C.M., McHugh J.B., Tang A.L., Owen J.H.,
RA   Teh B.T., McKean E.L., Glover T.W., Graham M.P., Prince M.E.P.,
RA   Chepeha D.B., Chinn S.B., Ferris R.L., Gollin S.M., Hoffmann T.K.,
RA   Bier H., Brakenhoff R.H., Bradford C.R., Carey T.E.;
RT   "Integration of high-risk human papillomavirus into cellular
RT   cancer-related genes in head and neck cancer cell lines.";
RL   Head Neck 39:840-852(2017).
//
RX   PubMed=28476783; DOI=10.21873/anticanres.11555;
RA   Hagemann J., Jacobi C., Hahn M., Schmid V., Welz C.,
RA   Schwenk-Zieger S., Stauber R.H., Baumeister P., Becker S.;
RT   "Spheroid-based 3D cell cultures enable personalized therapy testing
RT   and drug discovery in head and neck cancer.";
RL   Anticancer Res. 37:2201-2210(2017).
//
RX   PubMed=29156801; DOI=10.18632/oncotarget.21174;
RA   Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y.,
RA   Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J.,
RA   Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.;
RT   "Genomic characterization of human papillomavirus-positive and
RT   -negative human squamous cell cancer cell lines.";
RL   Oncotarget 8:86369-86383(2017).
//
RX   PubMed=33802339; DOI=10.3390/cancers13051069;
RA   Gottgens E.-L., Ansems M., Leenders W.P.J., Bussink J., Span P.N.;
RT   "Genotyping and characterization of HPV status, hypoxia, and
RT   radiosensitivity in 22 head and neck cancer cell lines.";
RL   Cancers (Basel) 13:1069.1-1069.12(2021).
//