Cellosaurus cell line MUTZ-8 (CVCL

Cellosaurus MUTZ-8 (CVCL_2130)

[Text version]

Cell line name

MUTZ-8

Synonyms

MUTZ8; Menschliche Und Tierische Zellkulture-8

Accession

CVCL_2130

Resource Identification Initiative

To cite this cell line use: MUTZ-8 (RRID:CVCL_2130)

Comments

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Doubling time: ~5 days (DOI=10.1007/978-3-642-59358-1_22); ~3-5 days (DSMZ=ACC-689).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.

Sequence variations

Mutation; HGNC; HGNC:6192; JAK2; Simple; p.Val617Phe (c.1849G>T); ClinVar=VCV000014662; Zygosity=Homozygous (PubMed=16408098).

Disease

Adult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

63Y

Category

Cancer cell line

STR profile

Source(s): DepMap=ACH-001577; DSMZ=ACC-689

Markers:

Amelogenin	X
CSF1PO	11
D2S1338	17,23
D3S1358	16
D5S818	12
D7S820	11
D8S1179	14
D13S317	9,11
D16S539	12
D18S51	12,15
D19S433	13,15
D21S11	28,29
FGA	18,20
Penta D	13,15
Penta E	12,20
TH01	9,9.3
TPOX	8,9
vWA	18

Web pages

http://www.cells-talk.com/index.php/page/copelibrary?key=MUTZ-8

Publications

PubMed=12145698; DOI=10.1038/sj.leu.2402601
Hu Z.-B., MacLeod R.A.F., Meyer C., Quentmeier H., Drexler H.G.
New acute myeloid leukemia-derived cell line: MUTZ-8 with 5q-.
Leukemia 16:1556-1561(2002)

DOI=10.1007/978-3-642-59358-1_22
Hu Z.-B., Quentmeier H., Meyer C., MacLeod R.A.F., Drexler H.G.
Establishment of the two cytokine-dependent acute myeloid leukemia-derived cell lines MUTZ-8 and MUTZ-11.
(In book chapter) Acute leukemias IX. Haematology and blood transfusion, Vol. 41; Hiddemann W., Haferlach T., Unterhalt M., Buechner T., Ritter J. (eds.); pp.122-127; Springer; Berlin; Germany (2003)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

Cross-references

Cell line collections (Providers)

DSMZ; ACC-689

Cell line databases/resources

cancercelllines; CVCL_2130
DepMap; ACH-001577
DSMZCellDive; ACC-689

Anatomy/cell type resources

BTO; BTO_0004768

Encyclopedic resources

Wikidata; Q54907104

Polymorphism and mutation databases

Cosmic; 975282
Cosmic; 1012053
Cosmic; 1281339
Cosmic; 1465960
Cosmic; 2306225

Entry history

Entry creation

04-Apr-2012

Last entry update

19-Dec-2024

Version number