ID   MUTZ-8
AC   CVCL_2130
SY   MUTZ8; Menschliche Und Tierische Zellkulture-8
DR   BTO; BTO:0004768
DR   cancercelllines; CVCL_2130
DR   Cosmic; 975282
DR   Cosmic; 1012053
DR   Cosmic; 1281339
DR   Cosmic; 1465960
DR   Cosmic; 2306225
DR   DepMap; ACH-001577
DR   DSMZ; ACC-689
DR   DSMZCellDive; ACC-689
DR   Wikidata; Q54907104
RX   DOI=10.1007/978-3-642-59358-1_22;
RX   PubMed=12145698;
RX   PubMed=16408098;
WW   http://www.cells-talk.com/index.php/page/copelibrary?key=MUTZ-8
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Doubling time: ~5 days (DOI=10.1007/978-3-642-59358-1_22); ~3-5 days (DSMZ=ACC-689).
CC   Sequence variation: Mutation; HGNC; 6192; JAK2; Simple; p.Val617Phe (c.1849G>T); ClinVar=VCV000014662; Zygosity=Homozygous (PubMed=16408098).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): DepMap=ACH-001577; DSMZ=ACC-689
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 9,11
ST   D16S539: 12
ST   D18S51: 12,15
ST   D19S433: 13,15
ST   D21S11: 28,29
ST   D2S1338: 17,23
ST   D3S1358: 16
ST   D5S818: 12
ST   D7S820: 11
ST   D8S1179: 14
ST   FGA: 18,20
ST   Penta D: 13,15
ST   Penta E: 12,20
ST   TH01: 9,9.3
ST   TPOX: 8,9
ST   vWA: 18
DI   NCIt; C9154; Adult acute myeloid leukemia
DI   ORDO; Orphanet_519; Acute myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   63Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 26
//
RX   DOI=10.1007/978-3-642-59358-1_22;
RA   Hu Z.-B., Quentmeier H., Meyer C., MacLeod R.A.F., Drexler H.G.;
RT   "Establishment of the two cytokine-dependent acute myeloid
RT   leukemia-derived cell lines MUTZ-8 and MUTZ-11.";
RL   (In) Acute leukemias IX. Haematology and blood transfusion, Vol. 41; Hiddemann W., Haferlach T., Unterhalt M., Buechner T., Ritter J. (eds.); pp.122-127; Springer; Berlin (2003).
//
RX   PubMed=12145698; DOI=10.1038/sj.leu.2402601;
RA   Hu Z.-B., MacLeod R.A.F., Meyer C., Quentmeier H., Drexler H.G.;
RT   "New acute myeloid leukemia-derived cell line: MUTZ-8 with 5q-.";
RL   Leukemia 16:1556-1561(2002).
//
RX   PubMed=16408098; DOI=10.1038/sj.leu.2404081;
RA   Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.;
RT   "JAK2 V617F tyrosine kinase mutation in cell lines derived from
RT   myeloproliferative disorders.";
RL   Leukemia 20:471-476(2006).
//