Cellosaurus cell line HROC69 T0 M2 (CVCL

Cellosaurus HROC69 T0 M2 (CVCL_1G07)

[Text version]

Cell line name

HROC69 T0 M2

Synonyms

HROC69X

Accession

CVCL_1G07

Resource Identification Initiative

To cite this cell line use: HROC69 T0 M2 (RRID:CVCL_1G07)

Comments

From: Linnebacher, Michael; University of Rostock; Rostock; Germany.
Population: Caucasian.
Characteristics: Established from a patient-derived xenograft established in female NMRI nu/nu mice.
Derived from site: In situ; Colon, ascending; UBERON=UBERON_0001156.

Sequence variations

Mutation; HGNC; HGNC:583; APC; Simple; p.Arg1450Ter (c.4348C>T); ClinVar=VCV000194585; Zygosity=Unspecified (PubMed=27087592).
Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Glu7Ter (c.19G>T); ClinVar=VCV000493079; Zygosity=Unspecified (PubMed=27087592).
Mutation; HGNC; HGNC:6769; SMAD3; Simple; p.Ala382Val (c.1145C>T); dbSNP=rs779602560; Zygosity=Unspecified (PubMed=27087592).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Unspecified (PubMed=27087592).

HLA typing

Source: Direct_author_submission

Class I
HLA-A	A*26:01,33:01
HLA-B	B*18:01,52:01
HLA-C	C*12:02,12:03
Class II
HLA-DQ	DQB1*03:01,06:01
HLA-DR	DRB1*11:04,15:02

Disease

Colon adenocarcinoma (NCIt: C4349)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Originate from same individual

CVCL_YD53 ! B-LCL-HROC69
CVCL_1G06 ! HROC69

Sex of cell

Male

Age at sampling

62Y

Category

Cancer cell line

STR profile

Source(s): CLS=300829; PubMed=27087592

Markers:

Amelogenin	X,Y
CSF1PO	10,11
D5S818	12,13
D7S820	10,12
D13S317	12
D16S539	12,13
TH01	7,10
TPOX	8,12
vWA	17

Publications

PubMed=27087592; DOI=10.1038/srep24671; PMCID=PMC4834534
Kuehn F., Mullins C.S., Krohn M., Harnack C., Ramer R., Kramer O.H., Klar E., Huhns M., Linnebacher M.
Establishment and characterization of HROC69 -- a Crohn s related colonic carcinoma cell line and its matched patient-derived xenograft.
Sci. Rep. 6:24671-24671(2016)

PubMed=31601052; DOI=10.3390/cancers11101520; PMCID=PMC6826890
Mullins C.S., Micheel B., Matschos S., Leuchter M., Burtin F., Krohn M., Huhns M., Klar E., Prall F., Linnebacher M.
Integrated biobanking and tumor model establishment of human colorectal carcinoma provides excellent tools for preclinical research.
Cancers (Basel) 11:1520.1-1520.18(2019)

Cross-references

Cell line collections (Providers)

CLS; 300829

Cell line databases/resources

cancercelllines; CVCL_1G07

Encyclopedic resources

Wikidata; Q54895302

Polymorphism and mutation databases

Cosmic; 2795027

Entry history

Entry creation

08-Jul-2015

Last entry update

19-Dec-2024

Version number