Cellosaurus cell line HROC69 (CVCL

Cellosaurus HROC69 (CVCL_1G06)

[Text version]

Cell line name

HROC69

Synonyms

HROC69P

Accession

CVCL_1G06

Resource Identification Initiative

To cite this cell line use: HROC69 (RRID:CVCL_1G06)

Comments

From: Linnebacher, Michael; University of Rostock; Rostock; Germany.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (PubMed=25926053).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Colon, ascending; UBERON=UBERON_0001156.

Sequence variations

Mutation; HGNC; HGNC:583; APC; Simple; p.Arg1450Ter (c.4348C>T); ClinVar=VCV000194585; Zygosity=Unspecified (PubMed=27087592).
Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Glu7Ter (c.19G>T); ClinVar=VCV000493079; Zygosity=Unspecified (PubMed=27087592).
Mutation; HGNC; HGNC:6769; SMAD3; Simple; p.Ala382Val (c.1145C>T); dbSNP=rs779602560; Zygosity=Unspecified (PubMed=27087592).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Unspecified (PubMed=27087592).

HLA typing

Source: Direct_author_submission

Class I
HLA-A	A*26:01,33:01
HLA-B	B*18:01,52:01
HLA-C	C*12:02,12:03
Class II
HLA-DQ	DQB1*03:01,06:01
HLA-DR	DRB1*11:04,15:02

Disease

Colon adenocarcinoma (NCIt: C4349)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Originate from same individual

CVCL_YD53 ! B-LCL-HROC69
CVCL_1G07 ! HROC69 T0 M2

Sex of cell

Male

Age at sampling

62Y

Category

Cancer cell line

STR profile

Source(s): CLS=300828; PubMed=25926053; PubMed=27087592

Markers:

Amelogenin	X,Y
CSF1PO	10,11
D5S818	12,13
D7S820	10,12
D13S317	11,12,13 (PubMed=25926053) 12 (CLS=300828; PubMed=27087592)
D16S539	11,12 (CLS=300828; PubMed=27087592) 12,13 (PubMed=25926053)
D21S11	29,33.2
TH01	7,9.3 (CLS=300828; PubMed=25926053) 7,10 (PubMed=27087592)
TPOX	8,12
vWA	17,19 (CLS=300828; PubMed=25926053) 17,20 (PubMed=27087592)

Publications

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

PubMed=27087592; DOI=10.1038/srep24671; PMCID=PMC4834534
Kuehn F., Mullins C.S., Krohn M., Harnack C., Ramer R., Kramer O.H., Klar E., Huhns M., Linnebacher M.
Establishment and characterization of HROC69 -- a Crohn s related colonic carcinoma cell line and its matched patient-derived xenograft.
Sci. Rep. 6:24671-24671(2016)

PubMed=31601052; DOI=10.3390/cancers11101520; PMCID=PMC6826890
Mullins C.S., Micheel B., Matschos S., Leuchter M., Burtin F., Krohn M., Huhns M., Klar E., Prall F., Linnebacher M.
Integrated biobanking and tumor model establishment of human colorectal carcinoma provides excellent tools for preclinical research.
Cancers (Basel) 11:1520.1-1520.18(2019)

Cross-references

Cell line collections (Providers)

CLS; 300828

Cell line databases/resources

cancercelllines; CVCL_1G06

Encyclopedic resources

Wikidata; Q54895301

Gene expression databases

GEO; GSM1448080

Polymorphism and mutation databases

Cosmic; 2795028

Entry history

Entry creation

08-Jul-2015

Last entry update

19-Dec-2024

Version number