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Cellosaurus UM-Chor1 (CVCL_1D68)

[Text version]
Cell line name UM-Chor1
Synonyms UM-CHOR-1; UMCHOR1; University of Michigan-Chordoma-1
Accession CVCL_1D68
Resource Identification Initiative To cite this cell line use: UM-Chor1 (RRID:CVCL_1D68)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Doubling time: ~5 days (PubMed=28430034); 5 days (Chordoma Foundation).
Omics: Deep exome analysis.
Omics: Genome sequenced.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Bone, cranium, clivus; UBERON=UBERON_0004108.
HLA typing Source: Chordoma Foundation
Class I
HLA-AA*02,03
Disease Clivus chordoma (NCIt: C5412)
Chordoma (ORDO: Orphanet_178)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 64Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3270; PubMed=27102572

Markers:
AmelogeninX,Y
CSF1PO11,12
D2S133818,20
D3S135818
D5S8189,13
D7S82011
D8S117912,13
D13S31712
D16S53912
D18S5114
D19S43314,16
D21S1127,31
FGA19,23
Penta D8,9
Penta E7
TH017,9.3
TPOX8,9
vWA15

Run an STR similarity search on this cell line
Web pages https://www.chordomafoundation.org/researchers/disease-models/um-chor1/
https://ahns.jnabstracts.com/2014/Detail.aspx?ID=57728
https://epostersonline.com/ifhnos2014/node/3423?view=true
Publications

PubMed=27102572; DOI=10.1002/path.4729; PMCID=PMC4922416
Scheipl S., Barnard M., Cottone L., Jorgensen M., Drewry D.H., Zuercher W.J., Turlais F., Ye H.-T., Leite A.P., Smith J.A., Leithner A., Moller P., Bruderlein S., Guppy N., Amary F., Tirabosco R., Strauss S.J., Pillay N., Flanagan A.M.
EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen.
J. Pathol. 239:320-334(2016)

PubMed=28515451; DOI=10.1038/s41598-017-02174-5; PMCID=PMC5435709
Jager D., Barth T.F.E., Bruderlein S., Scheuerle A., Rinner B., von Witzleben A., Lechel A., Meyer P., Mayer-Steinacker R., von Baer A., Schultheiss M., Wirtz C.R., Moller P., Mellert K.
HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and sacral chordomas.
Sci. Rep. 7:2032-2032(2017)

PubMed=28430034; DOI=10.3171/2016.10.JNS16877; PMCID=PMC5650943
Owen J.H., Komarck C.M., Wang A.C., Abuzeid W.M., Keep R.F., McKean E.L., Sullivan S., Fan X., Prince M.E.P.
UM-Chor1: establishment and characterization of the first validated clival chordoma cell line.
J. Neurosurg. 128:701-709(2018)

Cross-references
Cell line collections (Providers) ATCC; CRL-3270
Cell line databases/resources Cell_Model_Passport; SIDM01415
DepMap; ACH-001957
Encyclopedic resources Wikidata; Q54990767
Gene expression databases GEO; GSM2495967
GEO; GSM2495968
GEO; GSM2495969
Polymorphism and mutation databases Cosmic; 2663863
Entry history
Entry creation08-Jul-2015
Last entry update02-May-2024
Version number19