ID   UM-Chor1
AC   CVCL_1D68
SY   UM-CHOR-1; UMCHOR1; University of Michigan-Chordoma-1
DR   ATCC; CRL-3270
DR   Cell_Model_Passport; SIDM01415
DR   Cosmic; 2663863
DR   DepMap; ACH-001957
DR   GEO; GSM2495967
DR   GEO; GSM2495968
DR   GEO; GSM2495969
DR   Wikidata; Q54990767
RX   PubMed=27102572;
RX   PubMed=28430034;
RX   PubMed=28515451;
WW   https://www.chordomafoundation.org/researchers/disease-models/um-chor1/
WW   https://ahns.jnabstracts.com/2014/Detail.aspx?ID=57728
WW   https://epostersonline.com/ifhnos2014/node/3423?view=true
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Doubling time: ~5 days (PubMed=28430034); 5 days (Chordoma Foundation).
CC   HLA typing: A*02,03 (Chordoma Foundation).
CC   Omics: Deep exome analysis.
CC   Omics: Genome sequenced.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Bone, cranium, clivus; UBERON=UBERON_0004108.
ST   Source(s): ATCC=CRL-3270; PubMed=27102572
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 12
ST   D16S539: 12
ST   D18S51: 14
ST   D19S433: 14,16
ST   D21S11: 27,31
ST   D2S1338: 18,20
ST   D3S1358: 18
ST   D5S818: 9,13
ST   D7S820: 11
ST   D8S1179: 12,13
ST   FGA: 19,23
ST   Penta D: 8,9
ST   Penta E: 7
ST   TH01: 7,9.3
ST   TPOX: 8,9
ST   vWA: 15
DI   NCIt; C5412; Clivus chordoma
DI   ORDO; Orphanet_178; Chordoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   64Y
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 02-05-24; Version: 19
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RX   PubMed=27102572; DOI=10.1002/path.4729;
RA   Scheipl S., Barnard M., Cottone L., Jorgensen M., Drewry D.H.,
RA   Zuercher W.J., Turlais F., Ye H.-T., Leite A.P., Smith J.A., Leithner A.,
RA   Moller P., Bruderlein S., Guppy N., Amary F., Tirabosco R.,
RA   Strauss S.J., Pillay N., Flanagan A.M.;
RT   "EGFR inhibitors identified as a potential treatment for chordoma in a
RT   focused compound screen.";
RL   J. Pathol. 239:320-334(2016).
//
RX   PubMed=28430034; DOI=10.3171/2016.10.JNS16877;
RA   Owen J.H., Komarck C.M., Wang A.C., Abuzeid W.M., Keep R.F.,
RA   McKean E.L., Sullivan S., Fan X., Prince M.E.P.;
RT   "UM-Chor1: establishment and characterization of the first validated
RT   clival chordoma cell line.";
RL   J. Neurosurg. 128:701-709(2017).
//
RX   PubMed=28515451; DOI=10.1038/s41598-017-02174-5;
RA   Jager D., Barth T.F.E., Bruderlein S., Scheuerle A., Rinner B.,
RA   von Witzleben A., Lechel A., Meyer P., Mayer-Steinacker R., von Baer A.,
RA   Schultheiss M., Wirtz C.R., Moller P., Mellert K.;
RT   "HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and
RT   sacral chordomas.";
RL   Sci. Rep. 7:2032-2032(2017).
//