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Cellosaurus U-CH10 (CVCL_1D66)

[Text version]
Cell line name U-CH10
Synonyms UCH10
Accession CVCL_1D66
Resource Identification Initiative To cite this cell line use: U-CH10 (RRID:CVCL_1D66)
Comments Doubling time: 14 days (PubMed=26183925).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Bone, sacrum; UBERON=UBERON_0003690.
Sequence variations
Disease Sacral chordoma (NCIt: C129927)
Chordoma (ORDO: Orphanet_178)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 75Y
Category Cancer cell line
STR profile Source(s): PubMed=26183925; PubMed=27102572

Markers:
AmelogeninX
CSF1PO10,11
D2S133819
D3S135815,16
D5S81811
D7S8209,10 (PubMed=26183925)
10 (PubMed=27102572)
D8S11798,13
D13S3179,13
D16S53911,13
D18S5113
D19S43313,15
D21S1129,31
FGA24
Penta D9,13
Penta E18
TH018,9
TPOX11
vWA16

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Publications

PubMed=26183925; DOI=10.1158/0008-5472.CAN-14-3270
von Witzleben A., Goerttler L.T., Marienfeld R., Barth H., Lechel A., Mellert K., Bohm M., Kornmann M., Mayer-Steinacker R., von Baer A., Schultheiss M., Flanagan A.M., Moller P., Bruderlein S., Barth T.F.E.
Preclinical characterization of novel chordoma cell systems and their targeting by pharmocological inhibitors of the CDK4/6 cell-cycle pathway.
Cancer Res. 75:3823-3831(2015)

PubMed=27102572; DOI=10.1002/path.4729; PMCID=PMC4922416
Scheipl S., Barnard M., Cottone L., Jorgensen M., Drewry D.H., Zuercher W.J., Turlais F., Ye H.-T., Leite A.P., Smith J.A., Leithner A., Moller P., Bruderlein S., Guppy N., Amary F., Tirabosco R., Strauss S.J., Pillay N., Flanagan A.M.
EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen.
J. Pathol. 239:320-334(2016)

PubMed=28515451; DOI=10.1038/s41598-017-02174-5; PMCID=PMC5435709
Jager D., Barth T.F.E., Bruderlein S., Scheuerle A., Rinner B., von Witzleben A., Lechel A., Meyer P., Mayer-Steinacker R., von Baer A., Schultheiss M., Wirtz C.R., Moller P., Mellert K.
HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and sacral chordomas.
Sci. Rep. 7:2032-2032(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_1D66
Encyclopedic resources Wikidata; Q54973612
Gene expression databases GEO; GSM1673855
GEO; GSM1673856
Polymorphism and mutation databases Cosmic; 2663860
Entry history
Entry creation08-Jul-2015
Last entry update19-Dec-2024
Version number15