ID   U-CH10
AC   CVCL_1D66
SY   UCH10
DR   cancercelllines; CVCL_1D66
DR   Cosmic; 2663860
DR   GEO; GSM1673855
DR   GEO; GSM1673856
DR   Wikidata; Q54973612
RX   PubMed=26183925;
RX   PubMed=27102572;
RX   PubMed=28515451;
CC   Doubling time: 14 days (PubMed=26183925).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro72Arg (c.215C>G); ClinVar=VCV000012351; Zygosity=Unspecified (PubMed=28515451).
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Bone, sacrum; UBERON=UBERON_0003690.
ST   Source(s): PubMed=26183925; PubMed=27102572
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 9,13
ST   D16S539: 11,13
ST   D18S51: 13
ST   D19S433: 13,15
ST   D21S11: 29,31
ST   D2S1338: 19
ST   D3S1358: 15,16
ST   D5S818: 11
ST   D7S820: 9,10 (PubMed=26183925)
ST   D7S820: 10 (PubMed=27102572)
ST   D8S1179: 8,13
ST   FGA: 24
ST   Penta D: 9,13
ST   Penta E: 18
ST   TH01: 8,9
ST   TPOX: 11
ST   vWA: 16
DI   NCIt; C129927; Sacral chordoma
DI   ORDO; Orphanet_178; Chordoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   75Y
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 19-12-24; Version: 15
//
RX   PubMed=26183925; DOI=10.1158/0008-5472.CAN-14-3270;
RA   von Witzleben A., Goerttler L.T., Marienfeld R., Barth H., Lechel A.,
RA   Mellert K., Bohm M., Kornmann M., Mayer-Steinacker R., von Baer A.,
RA   Schultheiss M., Flanagan A.M., Moller P., Bruderlein S., Barth T.F.E.;
RT   "Preclinical characterization of novel chordoma cell systems and their
RT   targeting by pharmocological inhibitors of the CDK4/6 cell-cycle
RT   pathway.";
RL   Cancer Res. 75:3823-3831(2015).
//
RX   PubMed=27102572; DOI=10.1002/path.4729; PMCID=PMC4922416;
RA   Scheipl S., Barnard M., Cottone L., Jorgensen M., Drewry D.H.,
RA   Zuercher W.J., Turlais F., Ye H.-T., Leite A.P., Smith J.A., Leithner A.,
RA   Moller P., Bruderlein S., Guppy N., Amary F., Tirabosco R.,
RA   Strauss S.J., Pillay N., Flanagan A.M.;
RT   "EGFR inhibitors identified as a potential treatment for chordoma in a
RT   focused compound screen.";
RL   J. Pathol. 239:320-334(2016).
//
RX   PubMed=28515451; DOI=10.1038/s41598-017-02174-5; PMCID=PMC5435709;
RA   Jager D., Barth T.F.E., Bruderlein S., Scheuerle A., Rinner B.,
RA   von Witzleben A., Lechel A., Meyer P., Mayer-Steinacker R., von Baer A.,
RA   Schultheiss M., Wirtz C.R., Moller P., Mellert K.;
RT   "HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and
RT   sacral chordomas.";
RL   Sci. Rep. 7:2032-2032(2017).
//