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Cellosaurus BM-1604 (CVCL_1968)

[Text version]
Cell line name BM-1604
Synonyms BM 1604; BM1604
Accession CVCL_1968
Resource Identification Initiative To cite this cell line use: BM-1604 (RRID:CVCL_1968)
Comments Problematic cell line: Contaminated. Shown to be a DU145 derivative (PubMed=10508494; PubMed=20143388). Originally thought to originate from a 67 year old man with a primary prostatic adenocarcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00113.
Population: Caucasian.
Doubling time: 28 hours (PubMed=8054265); ~60 hours (Note=Highly variable) (DSMZ=ACC-298).
Omics: SNP array analysis.
Derived from site: Metastatic; Brain; UBERON=UBERON_0000955.
Sequence variations
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Asp84Tyr (c.250G>T) (p.Arg98Leu, c.293G>T); ClinVar=VCV000376306; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 9884; RB1; Simple; p.Lys715Ter (c.2143A>T); ClinVar=VCV001786615; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11389; STK11; Simple; p.Lys178fs*86 (c.532_536delAAGCC); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro223Leu (c.668C>T); ClinVar=VCV000234214; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Val274Phe (c.820G>T); ClinVar=VCV000376674; Zygosity=Heterozygous (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0105 (DU145)
Sex of cell Male
Age at sampling 69Y
Category Cancer cell line
STR profile Source(s): DSMZ; PubMed=25877200

Penta D9,13
Penta E12,14

Run an STR similarity search on this cell line
Web pages https://web.archive.org/web/20160703200713/http://capcelllines.ca:80/details.asp?id=71

PubMed=8054265; DOI=10.1038/bjc.1994.279
van Helden P.D., Wiid I.J.F., Hoal-van Helden E.G., Bey E., Cohen R.
Detection by DNA fingerprinting of somatic changes during the establishment of a new prostate cell line.
Br. J. Cancer 70:195-198(1994)

PubMed=10508494; DOI=10.1002/(SICI)1097-0215(19991112)83:4<555::AID-IJC19>3.0.CO;2-2
MacLeod R.A.F., Dirks W.G., Matsuo Y., Kaufmann M., Milch H., Drexler H.G.
Widespread intraspecies cross-contamination of human tumor cell lines arising at source.
Int. J. Cancer 83:555-563(1999)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

Cell line collections (Providers) DSMZ; ACC-298 - Discontinued
Cell line databases/resources CLO; CLO_0002001
cancercelllines; CVCL_1968
DSMZCellDive; ACC-298
IGRhCellID; BM1604
Anatomy/cell type resources BTO; BTO:0002015
Biological sample resources BioSample; SAMN03151637
BioSample; SAMN03470924
Encyclopedic resources Wikidata; Q54797440
Experimental variables resources EFO; EFO_0002117
Gene expression databases ArrayExpress; E-MTAB-38
Polymorphism and mutation databases Progenetix; CVCL_1968
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number28