ID   BM-1604
AC   CVCL_1968
SY   BM 1604; BM1604
DR   BTO; BTO:0002015
DR   CLO; CLO_0002001
DR   EFO; EFO_0002117
DR   ArrayExpress; E-MTAB-38
DR   BioSample; SAMN03151637
DR   BioSample; SAMN03470924
DR   cancercelllines; CVCL_1968
DR   DSMZ; ACC-298
DR   DSMZCellDive; ACC-298
DR   IGRhCellID; BM1604
DR   Progenetix; CVCL_1968
DR   Wikidata; Q54797440
RX   PubMed=8054265;
RX   PubMed=10508494;
RX   PubMed=20143388;
RX   PubMed=20215515;
RX   PubMed=25877200;
CC   Problematic cell line: Contaminated. Shown to be a DU145 derivative (PubMed=10508494; PubMed=20143388). Originally thought to originate from a 67 year old man with a primary prostatic adenocarcinoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00113.
CC   Population: Caucasian.
CC   Doubling time: 28 hours (PubMed=8054265); ~60 hours (Note=Highly variable) (DSMZ=ACC-298).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Asp84Tyr (c.250G>T) (p.Arg98Leu, c.293G>T); ClinVar=VCV000376306; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9884; RB1; Simple; p.Lys715Ter (c.2143A>T); ClinVar=VCV001786615; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11389; STK11; Simple; p.Lys178fs*86 (c.532_536delAAGCC); Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Pro223Leu (c.668C>T); ClinVar=VCV000234214; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Val274Phe (c.820G>T); ClinVar=VCV000376674; Zygosity=Heterozygous (from parent cell line).
CC   Omics: SNP array analysis.
CC   Discontinued: DSMZ; ACC-298; true.
CC   Derived from site: Metastatic; Brain; UBERON=UBERON_0000955.
ST   Source(s): DSMZ; PubMed=25877200
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11
ST   D13S317: 12,14
ST   D16S539: 11,13
ST   D18S51: 12
ST   D19S433: 12,13
ST   D21S11: 30,33,34
ST   D2S1338: 16
ST   D3S1358: 15,16
ST   D5S818: 10,14
ST   D7S820: 7,10
ST   D8S1179: 13,14
ST   FGA: 22
ST   Penta D: 9,13
ST   Penta E: 12,14
ST   TH01: 7
ST   TPOX: 11
ST   vWA: 17,18
DI   NCIt; C4863; Prostate carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0105 ! DU145
SX   Male
AG   69Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 28
RX   PubMed=8054265; DOI=10.1038/bjc.1994.279;
RA   van Helden P.D., Wiid I.J.F., Hoal-van Helden E.G., Bey E., Cohen R.;
RT   "Detection by DNA fingerprinting of somatic changes during the
RT   establishment of a new prostate cell line.";
RL   Br. J. Cancer 70:195-198(1994).
RX   PubMed=10508494; DOI=10.1002/(SICI)1097-0215(19991112)83:4<555::AID-IJC19>3.0.CO;2-2;
RA   MacLeod R.A.F., Dirks W.G., Matsuo Y., Kaufmann M., Milch H.,
RA   Drexler H.G.;
RT   "Widespread intraspecies cross-contamination of human tumor cell lines
RT   arising at source.";
RL   Int. J. Cancer 83:555-563(1999).
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).