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Cellosaurus Intestine 407 (CVCL_1907)

[Text version]
Cell line name Intestine 407
Synonyms intestine 407; Intestine-407; intestine-407; INT 407; Int 407; INT-407; Int-407; Int407; INT407; INT 407(HeLa derivative); HI407; Henle-407; 407; HEI
Accession CVCL_1907
Resource Identification Initiative To cite this cell line use: Intestine 407 (RRID:CVCL_1907)
Comments Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=4864103; PubMed=5641128; PubMed=566722; PubMed=1246601; PubMed=20143388). Originally thought to originate from embryonic intestinal cells (jejunum/ileum).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00008.
Population: African American.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Omics: Genome sequenced (low read coverage).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): ATCC; PubMed=11416159


Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx

PubMed=13431913; DOI=10.3181/00379727-94-23044
Foley G.E., Handler A.H.
Differentiation of normal and neoplastic cells maintained in tissue culture by implantation into normal hamsters.
Proc. Soc. Exp. Biol. Med. 94:661-664(1957)

PubMed=13475808; DOI=10.4049/jimmunol.79.1.54
Henle G., Deinhardt F.W.
The establishment of strains of human cells in tissue culture.
J. Immunol. 79:54-59(1957)

PubMed=14185313; DOI=10.1126/science.146.3641.241
Cell Culture Collection Committee
Animal cell strains. The Cell Culture Collection Committee has assembled and certified 23 strains of animal cells.
Science 146:241-243(1964)

Gartler S.M.
Genetic markers as tracers in cell culture.
Natl. Cancer Inst. Monogr. 26:167-195(1967)

PubMed=5641128; DOI=10.1038/217750a0
Gartler S.M.
Apparent Hela cell contamination of human heteroploid cell lines.
Nature 217:750-751(1968)

Stulberg C.S., Coriell L.L., Kniazeff A.J., Shannon J.E.
The animal cell culture collection.
In Vitro 5:1-16(1970)

PubMed=1246601; DOI=10.1126/science.1246601
Nelson-Rees W.A., Flandermeyer R.R.
HeLa cultures defined.
Science 191:96-98(1976)

PubMed=566722; DOI=10.1007/BF02616110
Lavappa K.S.
Survey of ATCC stocks of human cell lines for HeLa contamination.
In Vitro 14:469-475(1978)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=23925245; DOI=10.1038/nature12064
Adey A., Burton J.N., Kitzman J.O., Hiatt J.B., Lewis A.P., Martin B.K., Qiu R., Lee C., Shendure J.
The haplotype-resolved genome and epigenome of the aneuploid HeLa cancer cell line.
Nature 500:207-211(2013)

PubMed=34697958; DOI=10.1177/24725552211051963
Korch C.T., Capes-Davis A.
The extensive and expensive impacts of HEp-2 [HeLa], intestine 407 [HeLa], and other false cell lines in journal publications.
SLAS Discov. 26:1268-1279(2021)

Cell line collections (Providers) ATCC; CCL-6
BCRC; 60022 - Discontinued
ECACC; 85051004
RCB; RCB0553 - Discontinued
Cell line databases/resources CLO; CLO_0006953
CLO; CLO_0006954
CLO; CLO_0006955
CLDB; cl2895
CLDB; cl2896
CLDB; cl2897
CLDB; cl2898
Anatomy/cell type resources BTO; BTO:0000633
Biological sample resources BioSample; SAMN03151723
Encyclopedic resources Wikidata; Q54897826
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number30