ID   Intestine 407
AC   CVCL_1907
SY   intestine 407; Intestine-407; intestine-407; INT 407; Int 407; INT-407; Int-407; Int407; INT407; INT 407(HeLa derivative); HI407; Henle-407; 407; HEI
DR   BTO; BTO:0000633
DR   CLO; CLO_0006953
DR   CLO; CLO_0006954
DR   CLO; CLO_0006955
DR   CLDB; cl2895
DR   CLDB; cl2896
DR   CLDB; cl2897
DR   CLDB; cl2898
DR   BCRC; 60022
DR   BioSample; SAMN03151723
DR   ECACC; 85051004
DR   RCB; RCB0553
DR   Wikidata; Q54897826
RX   DOI=10.1007/BF02618370;
RX   PubMed=566722;
RX   PubMed=1246601;
RX   PubMed=4864103;
RX   PubMed=5641128;
RX   PubMed=11416159;
RX   PubMed=13431913;
RX   PubMed=13475808;
RX   PubMed=14185313;
RX   PubMed=20143388;
RX   PubMed=23925245;
RX   PubMed=34697958;
CC   Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=4864103; PubMed=5641128; PubMed=566722; PubMed=1246601; PubMed=20143388). Originally thought to originate from embryonic intestinal cells (jejunum/ileum).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00008.
CC   Population: African American.
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Omics: Genome sequenced (low read coverage).
CC   Discontinued: BCRC; 60022; true.
CC   Discontinued: RCB; RCB0553; true.
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
ST   Source(s): ATCC; PubMed=11416159
ST   Amelogenin: X
ST   CSF1PO: 9,10
ST   D13S317: 12,13.3
ST   D16S539: 9,10
ST   D18S51: 16
ST   D21S11: 27,28
ST   D5S818: 11,12
ST   D7S820: 8,12
ST   D8S1179: 12,13
ST   FGA: 18,21
ST   TH01: 7
ST   TPOX: 8,12
ST   vWA: 16,18
DI   NCIt; C27677; Human papillomavirus-related cervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0030 ! HeLa
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 31
RX   DOI=10.1007/BF02618370;
RA   Stulberg C.S., Coriell L.L., Kniazeff A.J., Shannon J.E.;
RT   "The animal cell culture collection.";
RL   In Vitro 5:1-16(1970).
RX   PubMed=566722; DOI=10.1007/BF02616110;
RA   Lavappa K.S.;
RT   "Survey of ATCC stocks of human cell lines for HeLa contamination.";
RL   In Vitro 14:469-475(1978).
RX   PubMed=1246601; DOI=10.1126/science.1246601;
RA   Nelson-Rees W.A., Flandermeyer R.R.;
RT   "HeLa cultures defined.";
RL   Science 191:96-98(1976).
RX   PubMed=4864103;
RA   Gartler S.M.;
RT   "Genetic markers as tracers in cell culture.";
RL   Natl. Cancer Inst. Monogr. 26:167-195(1967).
RX   PubMed=5641128; DOI=10.1038/217750a0;
RA   Gartler S.M.;
RT   "Apparent Hela cell contamination of human heteroploid cell lines.";
RL   Nature 217:750-751(1968).
RX   PubMed=11416159; DOI=10.1073/pnas.121616198;
RA   Masters J.R.W., Thomson J.A., Daly-Burns B., Reid Y.A., Dirks W.G.,
RA   Packer P., Toji L.H., Ohno T., Tanabe H., Arlett C.F., Kelland L.R.,
RA   Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.;
RT   "Short tandem repeat profiling provides an international reference
RT   standard for human cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001).
RX   PubMed=13431913; DOI=10.3181/00379727-94-23044;
RA   Foley G.E., Handler A.H.;
RT   "Differentiation of normal and neoplastic cells maintained in tissue
RT   culture by implantation into normal hamsters.";
RL   Proc. Soc. Exp. Biol. Med. 94:661-664(1957).
RX   PubMed=13475808; DOI=10.4049/jimmunol.79.1.54;
RA   Henle G., Deinhardt F.W.;
RT   "The establishment of strains of human cells in tissue culture.";
RL   J. Immunol. 79:54-59(1957).
RX   PubMed=14185313; DOI=10.1126/science.146.3641.241;
RG   Cell Culture Collection Committee;
RT   "Animal cell strains. The Cell Culture Collection Committee has
RT   assembled and certified 23 strains of animal cells.";
RL   Science 146:241-243(1964).
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
RX   PubMed=23925245; DOI=10.1038/nature12064;
RA   Adey A., Burton J.N., Kitzman J.O., Hiatt J.B., Lewis A.P.,
RA   Martin B.K., Qiu R., Lee C., Shendure J.;
RT   "The haplotype-resolved genome and epigenome of the aneuploid HeLa
RT   cancer cell line.";
RL   Nature 500:207-211(2013).
RX   PubMed=34697958; DOI=10.1177/24725552211051963;
RA   Korch C.T., Capes-Davis A.;
RT   "The extensive and expensive impacts of HEp-2 [HeLa], intestine 407
RT   [HeLa], and other false cell lines in journal publications.";
RL   SLAS Discov. 26:1268-1279(2021).