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Cellosaurus L-591 (CVCL_1867)

[Text version]
Cell line name L-591
Synonyms L 591; L591
Accession CVCL_1867
Resource Identification Initiative To cite this cell line use: L-591 (RRID:CVCL_1867)
Comments Part of: MD Anderson Cell Lines Project.
Population: Caucasian.
Virology: Contains a complete EBV genome (strain L591) which has been sequenced (PubMed=25787276).
Doubling time: ~72 hours (DSMZ=ACC-602).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Protein expression by reverse-phase protein arrays.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Disease Hodgkin lymphoma (NCIt: C9357)
Hodgkin lymphoma (ORDO: Orphanet_98293)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 31Y
Category Cancer cell line
STR profile Source(s): DSMZ

Markers:
AmelogeninX
CSF1PO10,11
D2S133817
D3S135815
D5S81811,12
D7S8209,13
D8S117912,13
D13S3177,13
D16S5399,12
D18S5112,19
D19S43312,16
D21S1129,30
FGA21,26
Penta D10,12
Penta E12,15
TH017,9.3
TPOX8,11
vWA16,21

Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/
Publications

PubMed=6303739; DOI=10.1055/s-2008-1069671
Kirchner H.H., Burrichter H., Stein H., Fonatsch C., Schaadt M., Ziegler A., Heit W., Diehl V.
Properties of Hodgkin cell lines. Possible significance for pathophysiology and clinical medicine.
Dtsch. Med. Wochenschr. 108:936-944(1983)

PubMed=6305805; DOI=10.1007/978-3-642-68761-7_81
Diehl V., Burrichter H., Schaadt M., Kirchner H.H., Fonatsch C., Stein H., Gerdes J., Heit W., Ziegler A.
Hodgkin's disease cell lines: characteristics and biological activities.
Haematol. Blood Transfus. 28:411-417(1983)

PubMed=2690233; DOI=10.1007/978-3-642-83781-4_5
Schaadt M., Burrichter H., Pfreundschuh M., Schell-Frederick E., Tesch H., Fonatsch C., Stein H., Diehl V.
Biology of Hodgkin cell lines.
Recent Results Cancer Res. 117:53-61(1989)

PubMed=12437638; DOI=10.1046/j.1365-2141.2002.03894.x
Vockerodt M., Belge G., Kube D., Irsch J., Siebert R., Tesch H., Diehl V., Wolf J., Bullerdiek J., Staratschek-Jox A.B.E.
An unbalanced translocation involving chromosome 14 is the probable cause for loss of potentially functional rearranged immunoglobulin heavy chain genes in the Epstein-Barr virus-positive Hodgkin's lymphoma-derived cell line L591.
Br. J. Haematol. 119:640-646(2002)

PubMed=17065008; DOI=10.1080/10428190600667721
Feuerborn A., Moritz C., von Bonin F., Dobbelstein M., Trumper L., Sturzenhofecker B., Kube D.
Dysfunctional p53 deletion mutants in cell lines derived from Hodgkin's lymphoma.
Leuk. Lymphoma 47:1932-1940(2006)

PubMed=19380639; DOI=10.1084/jem.20090528
Schmitz R., Hansmann M.-L., Bohle V., Martin-Subero J.I., Hartmann S., Mechtersheimer G., Klapper W., Vater I., Giefing M., Gesk S., Stanelle J., Siebert R., Kuppers R.
TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma.
J. Exp. Med. 206:981-989(2009)

PubMed=20454443; DOI=10.1155/2010/904767
Uphoff C.C., Denkmann S.A., Steube K.G., Drexler H.G.
Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human and other primate cell lines.
J. Biomed. Biotechnol. 2010:904767.1-904767.23(2010)

PubMed=25787276; DOI=10.1128/JVI.03614-14
Palser A.L., Grayson N.E., White R.E., Corton C., Correia S., Ba Abdullah M.M., Watson S.J., Cotten M., Arrand J.R., Murray P.G., Allday M.J., Rickinson A.B., Young L.S., Farrell P.J., Kellam P.
Genome diversity of Epstein-Barr virus from multiple tumor types and normal infection.
J. Virol. 89:5222-5237(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29533902; DOI=10.1515/hsz-2017-0321
Drexler H.G., Pommerenke C., Eberth S., Nagel S.
Hodgkin lymphoma cell lines: to separate the wheat from the chaff.
Biol. Chem. 399:511-523(2018)

Cross-references
Cell line collections (Providers) CLS; 300202
DSMZ; ACC-602
Cell line databases/resources DSMZCellDive; ACC-602
Biological sample resources BioSample; SAMN03473498
Encyclopedic resources Wikidata; Q54900877
Polymorphism and mutation databases Cosmic; 1289697
Cosmic; 1432038
Cosmic; 2464305
IARC_TP53; 23614
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number23