ID   L-591
AC   CVCL_1867
SY   L 591; L591
DR   BioSample; SAMN03473498
DR   CLS; 300202
DR   Cosmic; 1289697
DR   Cosmic; 1432038
DR   Cosmic; 2464305
DR   DSMZ; ACC-602
DR   DSMZCellDive; ACC-602
DR   IARC_TP53; 23614
DR   Wikidata; Q54900877
RX   PubMed=2690233;
RX   PubMed=6303739;
RX   PubMed=6305805;
RX   PubMed=12437638;
RX   PubMed=17065008;
RX   PubMed=19380639;
RX   PubMed=20454443;
RX   PubMed=25787276;
RX   PubMed=28196595;
RX   PubMed=29533902;
WW   https://tcpaportal.org/mclp/
CC   Part of: MD Anderson Cell Lines Project.
CC   Population: Caucasian.
CC   Virology: Contains a complete EBV genome (strain L591) which has been sequenced (PubMed=25787276).
CC   Doubling time: ~72 hours (DSMZ=ACC-602).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): DSMZ
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 7,13
ST   D16S539: 9,12
ST   D18S51: 12,19
ST   D19S433: 12,16
ST   D21S11: 29,30
ST   D2S1338: 17
ST   D3S1358: 15
ST   D5S818: 11,12
ST   D7S820: 9,13
ST   D8S1179: 12,13
ST   FGA: 21,26
ST   Penta D: 10,12
ST   Penta E: 12,15
ST   TH01: 7,9.3
ST   TPOX: 8,11
ST   vWA: 16,21
DI   NCIt; C9357; Hodgkin lymphoma
DI   ORDO; Orphanet_98293; Hodgkin lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   31Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 23
//
RX   PubMed=2690233; DOI=10.1007/978-3-642-83781-4_5;
RA   Schaadt M., Burrichter H., Pfreundschuh M., Schell-Frederick E.,
RA   Tesch H., Fonatsch C., Stein H., Diehl V.;
RT   "Biology of Hodgkin cell lines.";
RL   Recent Results Cancer Res. 117:53-61(1989).
//
RX   PubMed=6303739; DOI=10.1055/s-2008-1069671;
RA   Kirchner H.H., Burrichter H., Stein H., Fonatsch C., Schaadt M.,
RA   Ziegler A., Heit W., Diehl V.;
RT   "Properties of Hodgkin cell lines. Possible significance for
RT   pathophysiology and clinical medicine.";
RL   Dtsch. Med. Wochenschr. 108:936-944(1983).
//
RX   PubMed=6305805; DOI=10.1007/978-3-642-68761-7_81;
RA   Diehl V., Burrichter H., Schaadt M., Kirchner H.H., Fonatsch C.,
RA   Stein H., Gerdes J., Heit W., Ziegler A.;
RT   "Hodgkin's disease cell lines: characteristics and biological
RT   activities.";
RL   Haematol. Blood Transfus. 28:411-417(1983).
//
RX   PubMed=12437638; DOI=10.1046/j.1365-2141.2002.03894.x;
RA   Vockerodt M., Belge G., Kube D., Irsch J., Siebert R., Tesch H.,
RA   Diehl V., Wolf J., Bullerdiek J., Staratschek-Jox A.B.E.;
RT   "An unbalanced translocation involving chromosome 14 is the probable
RT   cause for loss of potentially functional rearranged immunoglobulin
RT   heavy chain genes in the Epstein-Barr virus-positive Hodgkin's
RT   lymphoma-derived cell line L591.";
RL   Br. J. Haematol. 119:640-646(2002).
//
RX   PubMed=17065008; DOI=10.1080/10428190600667721;
RA   Feuerborn A., Moritz C., von Bonin F., Dobbelstein M., Trumper L.,
RA   Sturzenhofecker B., Kube D.;
RT   "Dysfunctional p53 deletion mutants in cell lines derived from
RT   Hodgkin's lymphoma.";
RL   Leuk. Lymphoma 47:1932-1940(2006).
//
RX   PubMed=19380639; DOI=10.1084/jem.20090528;
RA   Schmitz R., Hansmann M.-L., Bohle V., Martin-Subero J.I., Hartmann S.,
RA   Mechtersheimer G., Klapper W., Vater I., Giefing M., Gesk S.,
RA   Stanelle J., Siebert R., Kuppers R.;
RT   "TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and
RT   primary mediastinal B cell lymphoma.";
RL   J. Exp. Med. 206:981-989(2009).
//
RX   PubMed=20454443; DOI=10.1155/2010/904767;
RA   Uphoff C.C., Denkmann S.A., Steube K.G., Drexler H.G.;
RT   "Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human
RT   and other primate cell lines.";
RL   J. Biomed. Biotechnol. 2010:904767.1-904767.23(2010).
//
RX   PubMed=25787276; DOI=10.1128/JVI.03614-14;
RA   Palser A.L., Grayson N.E., White R.E., Corton C., Correia S.,
RA   Ba Abdullah M.M., Watson S.J., Cotten M., Arrand J.R., Murray P.G.,
RA   Allday M.J., Rickinson A.B., Young L.S., Farrell P.J., Kellam P.;
RT   "Genome diversity of Epstein-Barr virus from multiple tumor types and
RT   normal infection.";
RL   J. Virol. 89:5222-5237(2015).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005;
RA   Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P.,
RA   Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L.,
RA   Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D.,
RA   Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B.,
RA   Liang H.;
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=29533902; DOI=10.1515/hsz-2017-0321;
RA   Drexler H.G., Pommerenke C., Eberth S., Nagel S.;
RT   "Hodgkin lymphoma cell lines: to separate the wheat from the chaff.";
RL   Biol. Chem. 399:511-523(2018).
//