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Cellosaurus KG-1a (CVCL_1824)

[Text version]
Cell line name KG-1a
Synonyms KG-1A; KG1A; KG1a
Accession CVCL_1824
Resource Identification Initiative To cite this cell line use: KG-1a (RRID:CVCL_1824)
Comments Population: Caucasian.
Characteristics: Less differentiated subline of KG-1, composed of undifferentiated promyeloblasts.
Doubling time: ~45 hours (CLS=300234); ~50 hours (DSMZ=ACC-421).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; 3688; FGFR1 + HGNC; 23098; FGFR1OP2; Name(s)=FGFR1OP2-FGFR1 (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; c.672+1G>A; ClinVar=VCV000216078; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
Disease Adult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0374 (KG-1)
Sex of cell Male
Age at sampling 59Y
Category Cancer cell line
STR profile Source(s): ATCC=CCL-246.1; CCRID=1102HUM-NIFDC00028; CLS=300234; COG; DSMZ=ACC-421; ECACC=91030101; PubMed=11416159; PubMed=25877200; RCB=RCB1928; TKG=TKG 0402

Markers:
AmelogeninX,Y
CSF1PO7
D2S133820,23
D3S135815,16
D5S81813
D7S8208,10
D8S117913,14 (ATCC=CCL-246.1; CCRID=1102HUM-NIFDC00028; CLS=300234; DSMZ=ACC-421; PubMed=11416159; PubMed=25877200)
14 (COG)
D13S31711,12
D16S53910,11
D18S5110.2,18
D19S43311,16.2 (ATCC=CCL-246.1; COG)
11,17 (DSMZ=ACC-421)
16.2 (PubMed=25877200)
D21S1128,29
FGA22
Penta D8,9
Penta E7,13
TH017,8
TPOX7 (PubMed=25877200)
7,9 (ATCC=CCL-246.1; CCRID=1102HUM-NIFDC00028; CLS=300234; COG; DSMZ=ACC-421; ECACC=91030101; RCB=RCB1928; TKG=TKG 0402)
vWA14,19

Run an STR similarity search on this cell line
Web pages http://www.cells-talk.com/index.php/page/copelibrary?key=KG-1
https://www.atcc.org/en/support/technical-support/faqs/description-of-normal-growth-and-morphology-of-atcc-ccl-246-1
Publications

PubMed=6967340; DOI=10.1182/blood.V56.2.265.265
Koeffler H.P., Billing R.J., Lusis A.J., Sparkes R.S., Golde D.W.
An undifferentiated variant derived from the human acute myelogenous leukemia cell line (KG-1).
Blood 56:265-273(1980)

PubMed=3094604; DOI=10.1182/blood.V68.5.1101.1101
Furley A.J.W., Reeves B.R., Mizutani S., Altass L.J., Watt S.M., Jacob M.C., van den Elsen P., Terhorst C.P., Greaves M.F.
Divergent molecular phenotypes of KG1 and KG1a myeloid cell lines.
Blood 68:1101-1107(1986)

PubMed=8558913
Morita S., Tsuchiya S., Fujie H., Itano M., Ohashi Y., Minegishi M., Imaizumi M., Endo M., Takano N., Konno T.
Cell surface c-kit receptors in human leukemia cell lines and pediatric leukemia: selective preservation of c-kit expression on megakaryoblastic cell lines during adaptation to in vitro culture.
Leukemia 10:102-105(1996)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
Masters J.R.W., Thomson J.A., Daly-Burns B., Reid Y.A., Dirks W.G., Packer P., Toji L.H., Ohno T., Tanabe H., Arlett C.F., Kelland L.R., Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

PubMed=22844360; DOI=10.3892/ol.2012.709; PMCID=PMC3402744
Pelliccia F., Ubertini V., Bosco N.
The importance of molecular cytogenetic analysis prior to using cell lines in research: the case of the KG-1a leukemia cell line.
Oncol. Lett. 4:237-240(2012)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

Cross-references
Cell line collections (Providers) ATCC; CCL-246.1
BCRC; 60224
CLS; 300234
DSMZ; ACC-421
ECACC; 91030101
IZSLER; BS TCL 196
NCBI_Iran; C520
RCB; RCB1928
TKG; TKG 0402
Ubigene; YC-C083
Cell line databases/resources CLO; CLO_0007095
CLO; CLO_0051561
CLDB; cl3026
CLDB; cl3027
cancercelllines; CVCL_1824
CCRID; 1102HUM-NIFDC00028
DSMZCellDive; ACC-421
LINCS_LDP; LCL-1057
Lonza; 835
Anatomy/cell type resources BTO; BTO:0005076
Biological sample resources BioSample; SAMN01821644
BioSample; SAMN03470993
Chemistry resources ChEMBL-Cells; CHEMBL4295408
ChEMBL-Targets; CHEMBL4296453
PubChem_Cell_line; CVCL_1824
Encyclopedic resources Wikidata; Q54899835
Gene expression databases GEO; GSM1374598
GEO; GSM1446747
Polymorphism and mutation databases Cosmic; 787444
Cosmic; 821042
Cosmic; 850388
Cosmic; 985582
Cosmic; 994174
Cosmic; 1127254
Cosmic; 1319553
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number37