ID   KG-1a
AC   CVCL_1824
SY   KG-1A; KG1A; KG1a
DR   BTO; BTO:0005076
DR   CLO; CLO_0007095
DR   CLO; CLO_0051561
DR   CLDB; cl3026
DR   CLDB; cl3027
DR   ATCC; CCL-246.1
DR   BCRC; 60224
DR   BioSample; SAMN01821644
DR   BioSample; SAMN03470993
DR   cancercelllines; CVCL_1824
DR   CCRID; 1102HUM-NIFDC00028
DR   ChEMBL-Cells; CHEMBL4295408
DR   ChEMBL-Targets; CHEMBL4296453
DR   CLS; 300234
DR   Cosmic; 787444
DR   Cosmic; 821042
DR   Cosmic; 850388
DR   Cosmic; 985582
DR   Cosmic; 994174
DR   Cosmic; 1127254
DR   Cosmic; 1319553
DR   DSMZ; ACC-421
DR   DSMZCellDive; ACC-421
DR   ECACC; 91030101
DR   GEO; GSM1374598
DR   GEO; GSM1446747
DR   IZSLER; BS TCL 196
DR   LINCS_LDP; LCL-1057
DR   Lonza; 835
DR   NCBI_Iran; C520
DR   PubChem_Cell_line; CVCL_1824
DR   RCB; RCB1928
DR   TKG; TKG 0402
DR   Ubigene; YC-C083
DR   Wikidata; Q54899835
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=3094604;
RX   PubMed=6967340;
RX   PubMed=8558913;
RX   PubMed=11416159;
RX   PubMed=22844360;
RX   PubMed=25877200;
WW   http://www.cells-talk.com/index.php/page/copelibrary?key=KG-1
WW   https://www.atcc.org/en/support/technical-support/faqs/description-of-normal-growth-and-morphology-of-atcc-ccl-246-1
CC   Population: Caucasian.
CC   Characteristics: Less differentiated subline of KG-1, composed of undifferentiated promyeloblasts.
CC   Doubling time: ~45 hours (CLS=300234); ~50 hours (DSMZ=ACC-421).
CC   Sequence variation: Gene fusion; HGNC; 3688; FGFR1 + HGNC; 23098; FGFR1OP2; Name(s)=FGFR1OP2-FGFR1 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; c.672+1G>A; ClinVar=VCV000216078; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
ST   Source(s): ATCC; CCRID; CLS; COG; DSMZ; ECACC; PubMed=11416159; PubMed=25877200; RCB; TKG
ST   Amelogenin: X,Y
ST   CSF1PO: 7
ST   D13S317: 11,12
ST   D16S539: 10,11
ST   D18S51: 10.2,18
ST   D19S433: 11,16.2 (COG)
ST   D19S433: 11,17 (DSMZ)
ST   D19S433: 16.2 (PubMed=25877200)
ST   D21S11: 28,29
ST   D2S1338: 20,23
ST   D3S1358: 15,16
ST   D5S818: 13
ST   D7S820: 8,10
ST   D8S1179: 13,14 (CCRID; CLS; DSMZ; PubMed=11416159; PubMed=25877200)
ST   D8S1179: 14 (COG)
ST   FGA: 22
ST   Penta D: 8,9
ST   Penta E: 7,13
ST   TH01: 7,8
ST   TPOX: 7 (PubMed=25877200)
ST   TPOX: 7,9 (ATCC; CCRID; CLS; COG; DSMZ; ECACC; RCB; TKG)
ST   vWA: 14,19
DI   NCIt; C9154; Adult acute myeloid leukemia
DI   ORDO; Orphanet_519; Acute myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0374 ! KG-1
SX   Male
AG   59Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 36
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001).
//
RX   PubMed=3094604; DOI=10.1182/blood.V68.5.1101.1101;
RA   Furley A.J.W., Reeves B.R., Mizutani S., Altass L.J., Watt S.M.,
RA   Jacob M.C., van den Elsen P., Terhorst C.P., Greaves M.F.;
RT   "Divergent molecular phenotypes of KG1 and KG1a myeloid cell lines.";
RL   Blood 68:1101-1107(1986).
//
RX   PubMed=6967340; DOI=10.1182/blood.V56.2.265.265;
RA   Koeffler H.P., Billing R.J., Lusis A.J., Sparkes R.S., Golde D.W.;
RT   "An undifferentiated variant derived from the human acute myelogenous
RT   leukemia cell line (KG-1).";
RL   Blood 56:265-273(1980).
//
RX   PubMed=8558913;
RA   Morita S., Tsuchiya S., Fujie H., Itano M., Ohashi Y., Minegishi M.,
RA   Imaizumi M., Endo M., Takano N., Konno T.;
RT   "Cell surface c-kit receptors in human leukemia cell lines and
RT   pediatric leukemia: selective preservation of c-kit expression on
RT   megakaryoblastic cell lines during adaptation to in vitro culture.";
RL   Leukemia 10:102-105(1996).
//
RX   PubMed=11416159; DOI=10.1073/pnas.121616198;
RA   Masters J.R.W., Thomson J.A., Daly-Burns B., Reid Y.A., Dirks W.G.,
RA   Packer P., Toji L.H., Ohno T., Tanabe H., Arlett C.F., Kelland L.R.,
RA   Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.;
RT   "Short tandem repeat profiling provides an international reference
RT   standard for human cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001).
//
RX   PubMed=22844360; DOI=10.3892/ol.2012.709;
RA   Pelliccia F., Ubertini V., Bosco N.;
RT   "The importance of molecular cytogenetic analysis prior to using cell
RT   lines in research: the case of the KG-1a leukemia cell line.";
RL   Oncol. Lett. 4:237-240(2012).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//