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Cellosaurus 1.1B4 (CVCL_1778)

[Text version]
Cell line name 1.1B4
Accession CVCL_1778
Resource Identification Initiative To cite this cell line use: 1.1B4 (RRID:CVCL_1778)
Comments Group: Patented cell line.
Problematic cell line: Misidentified/contaminated. Originally thought to be an hybrid cell line obtained by electrofusion of a primary culture of human pancreatic islets with the PANC-1 but found to contain rat DNA (ECACC=10012801; PubMed=34341375).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00599.
Registration: International Depositary Authority, European Collection of Cell Cultures (ECACC); 00112811.
Characteristics: Insulin secreting.
Doubling time: 23 +- 1.7 hours (PubMed=21515691); ~20 hours (ECACC=10012801).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Hierarchy Parent: CVCL_0480 (PANC-1)
Category Hybrid cell line
STR profile Source(s): ECACC=10012801; Patent=US20040005702

Markers:
AmelogeninX
CSF1PO10,12
D13S31711
D16S53911
D18S5112
D21S1128
D3S135817
D5S81811,13
D7S8208
D8S117914,15
FGA21
TH017,8
TPOX8,11
vWA15

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

Patent=US20040005702
Flatt P.R., McClenaghan N.H.
Insulin producing cell-line.
Patent number US20040005702, 08-Jan-2004

PubMed=21515691; DOI=10.1074/jbc.M111.226795; PMCID=PMC3121343
McCluskey J.T., Hamid M., Guo-Parke H., McClenaghan N.H., Gomis R., Flatt P.R.
Development and functional characterization of insulin-releasing human pancreatic beta cell lines produced by electrofusion.
J. Biol. Chem. 286:21982-21992(2011)

PubMed=23985558; DOI=10.4161/isl.26184
Vasu S., McClenaghan N.H., McCluskey J.T., Flatt P.R.
Cellular responses of novel human pancreatic beta-cell line, 1.1B4 to hyperglycemia.
Islets 5:170-177(2013)

PubMed=34341375; DOI=10.1038/s41598-021-94878-y; PMCID=PMC8329048
Chaffey J.R., Young J., Leslie K.A., Partridge K., Akhbari P., Dhayal S., Hill J.L., Wedgwood K.C.A., Burnett E.C., Russell M.A., Richardson S.J., Morgan N.G.
Investigation of the utility of the 1.1B4 cell as a model human beta cell line for study of persistent enteroviral infection.
Sci. Rep. 11:15624.1-15624.13(2021)

Cross-references
Cell line collections (Providers) ECACC; 10012801 - Discontinued
KCB; KCB 2015017YJ
Cell line databases/resources CCRID; 5301HUM-KCB15017YJ
Encyclopedic resources Wikidata; Q54423235
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number16