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Cellosaurus 1.1B4 (CVCL_1778)

[Text version]
Cell line name 1.1B4
Accession CVCL_1778
Resource Identification Initiative To cite this cell line use: 1.1B4 (RRID:CVCL_1778)
Comments Group: Patented cell line.
Problematic cell line: Misidentified/contaminated. Originally thought to be an hybrid cell line obtained by electrofusion of a primary culture of human pancreatic islets with the PANC-1 but found to contain rat DNA (ECACC).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00599.
Registration: International Depositary Authority, European Collection of Cell Cultures (ECACC); 00112811.
Characteristics: Insulin secreting.
Doubling time: 23 +- 1.7 hours (PubMed=21515691); ~20 hours (ECACC=10012801).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Hierarchy Parent: CVCL_0480 (PANC-1)
Category Hybrid cell line
STR profile Source(s): ECACC; Patent=US20040005702

Markers:
AmelogeninX
CSF1PO10,12
D13S31711
D16S53911
D18S5112
D21S1128
D3S135817
D5S81811,13
D7S8208
D8S117914,15
FGA21
TH017,8
TPOX8,11
vWA15

Run an STR similarity search on this cell line
Web pages https://www.phe-culturecollections.org.uk/technical/discontinued-ecacc-cell-lines.aspx
https://www.phe-culturecollections.org.uk/products/celllines/discontinued-ecacc-cell-lines/11b4.aspx
https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
Publications

Patent=US20040005702
Flatt P.R., McClenaghan N.H.
Insulin producing cell-line.
Patent number US20040005702, 08-Jan-2004

PubMed=21515691; DOI=10.1074/jbc.M111.226795
McCluskey J.T., Hamid M., Hong G.-P., McClenaghan N.H., Gomis R., Flatt P.R.
Development and functional characterization of insulin-releasing human pancreatic beta cell lines produced by electrofusion.
J. Biol. Chem. 286:21982-21992(2011)

PubMed=23985558; DOI=10.4161/isl.26184
Vasu S., McClenaghan N.H., McCluskey J.T., Flatt P.R.
Cellular responses of novel human pancreatic beta-cell line, 1.1B4 to hyperglycemia.
Islets 5:170-177(2013)

Cross-references
Cell line collections ECACC; 10012801 - Discontinued
KCB; KCB 2015017YJ
Cell line databases/resources CCRID; 5301HUM-KCB15017YJ
Encyclopedic resources Wikidata; Q54423235
Entry history
Entry creation04-Apr-2012
Last entry update21-Mar-2023
Version number13