ID   1.1B4
AC   CVCL_1778
DR   CCRID; 5301HUM-KCB15017YJ
DR   ECACC; 10012801
DR   KCB; KCB 2015017YJ
DR   Wikidata; Q54423235
RX   Patent=US20040005702;
RX   PubMed=21515691;
RX   PubMed=23985558;
CC   Group: Patented cell line.
CC   Problematic cell line: Misidentified/contaminated. Originally thought to be an hybrid cell line obtained by electrofusion of a primary culture of human pancreatic islets with the PANC-1 but found to contain rat DNA (ECACC=10012801).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00599.
CC   Registration: International Depositary Authority, European Collection of Cell Cultures (ECACC); 00112811.
CC   Characteristics: Insulin secreting.
CC   Doubling time: 23 +- 1.7 hours (PubMed=21515691); ~20 hours (ECACC=10012801).
CC   Discontinued: ECACC; 10012801; true.
ST   Source(s): ECACC; Patent=US20040005702
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 11
ST   D16S539: 11
ST   D18S51: 12
ST   D21S11: 28
ST   D3S1358: 17
ST   D5S818: 11,13
ST   D7S820: 8
ST   D8S1179: 14,15
ST   FGA: 21
ST   TH01: 7,8
ST   TPOX: 8,11
ST   vWA: 15
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
HI   CVCL_0480 ! PANC-1
CA   Hybrid cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 14
RX   Patent=US20040005702;
RA   Flatt P.R., McClenaghan N.H.;
RT   "Insulin producing cell-line.";
RL   Patent number US20040005702, 08-Jan-2004.
RX   PubMed=21515691; DOI=10.1074/jbc.M111.226795;
RA   McCluskey J.T., Hamid M., Guo-Parke H., McClenaghan N.H., Gomis R.,
RA   Flatt P.R.;
RT   "Development and functional characterization of insulin-releasing
RT   human pancreatic beta cell lines produced by electrofusion.";
RL   J. Biol. Chem. 286:21982-21992(2011).
RX   PubMed=23985558; DOI=10.4161/isl.26184;
RA   Vasu S., McClenaghan N.H., McCluskey J.T., Flatt P.R.;
RT   "Cellular responses of novel human pancreatic beta-cell line, 1.1B4 to
RT   hyperglycemia.";
RL   Islets 5:170-177(2013).