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Cellosaurus MZ-MEL-2 (CVCL_1435)

[Text version]
Cell line name MZ-MEL-2
Synonyms Mz-Mel-2; MZ Mel 2; MZ-2 Mel; MZ2-MEL; MZ2-Mel; MZ2-mel; MZ2MEL
Accession CVCL_1435
Resource Identification Initiative To cite this cell line use: MZ-MEL-2 (RRID:CVCL_1435)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Abdomen; UBERON=UBERON_0000916.
Sequence variations
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (PubMed=25728708; Cosmic-CLP; DepMap).
  • Mutation; HGNC; 9829; RAF1; Simple; p.Ser257Leu (c.770C>T); ClinVar=VCV000013957; Zygosity=Heterozygous (Cosmic-CLP; DepMap).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.15
East Asian, North0.41
East Asian, South0.66
South Asian0.41
European, North64.57
European, South33.8
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_C5U4 (MZ2-MEL.3.0)
Originate from same individual CVCL_C5U5 ! MZ2-EBV
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): Cosmic-CLP

Markers:
AmelogeninX
CSF1PO10
D5S8189,11
D7S82010,12
D13S31712
D16S53912,13
TH018,9.3
TPOX8,12
vWA16,18

Run an STR similarity search on this cell line
Publications

PubMed=3972469; DOI=10.1002/ijc.2910350215
Vessiere-Louveaux F.M.Y.R., Darville M., Knuth A., Boon T.
Use of irradiated mouse fibroblasts to improve the cloning and adaptation to culture of human melanoma cells.
Int. J. Cancer 35:231-235(1985)

PubMed=2529220; DOI=10.1002/ijc.2910440413
van den Eynde B.J., Hainaut P., Herin M., Knuth A., Lemoine C., Weynants P., van der Bruggen P., Fauchet R., Boon T.
Presence on a human melanoma of multiple antigens recognized by autologous CTL.
Int. J. Cancer 44:634-640(1989)

PubMed=8509230; DOI=10.1002/ijc.2910540329
Rimoldi D., Romero P., Carrel S.
The human melanoma antigen-encoding gene, MAGE-1, is expressed by other tumour cells of neuroectodermal origin such as glioblastomas and neuroblastomas.
Int. J. Cancer 54:527-528(1993)

PubMed=8566071; DOI=10.1002/eji.1830260135
Brichard V.G., Herman J., Van Pel A., Wildmann C., Gaugler B., Wolfel T., Boon T., Lethe B.
A tyrosinase nonapeptide presented by HLA-B44 is recognized on a human melanoma by autologous cytolytic T lymphocytes.
Eur. J. Immunol. 26:224-230(1996)

PubMed=9637538; DOI=10.4049/jimmunol.160.12.6188
Gueguen M., Patard J.-J., Gaugler B., Brasseur F., Renauld J.-C., Van Cangh P.J., Boon T., van den Eynde B.J.
An antigen recognized by autologous CTLs on a human bladder carcinoma.
J. Immunol. 160:6188-6194(1998)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=25502142; DOI=10.1038/ncomms6712
Muller J., Krijgsman O., Tsoi J., Robert L., Hugo W., Song C., Kong X.-J., Possik P.A., Cornelissen-Steijger P.D.M., Geukes Foppen M.H., Kemper K., Goding C.R., McDermott U., Blank C., Haanen J.B.A.G., Graeber T.G., Ribas A., Lo R.S., Peeper D.S.
Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma.
Nat. Commun. 5:5712.1-5712.15(2014)

PubMed=25728708; DOI=10.1111/pcmr.12364
Vogel C.J., Smit M.A., Maddalo G., Possik P.A., Sparidans R.W., van der Burg S.H., Verdegaal E.M.E., Heck A.J.R., Samatar A.A., Beijnen J.H., Altelaar A.F.M., Peeper D.S.
Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK.
Pigment Cell Melanoma Res. 28:307-317(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line databases/resources CLO; CLO_0037132
cancercelllines; CVCL_1435
Cell_Model_Passport; SIDM00179
Cosmic-CLP; 971777
DepMap; ACH-002165
LINCS_LDP; LCL-1278
Chemistry resources ChEMBL-Cells; CHEMBL3308272
ChEMBL-Targets; CHEMBL2366226
GDSC; 971777
PharmacoDB; MZ2MEL_976_2019
PubChem_Cell_line; CVCL_1435
Encyclopedic resources Wikidata; Q54907223
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1507939
GEO; GSM1670140
Polymorphism and mutation databases Cosmic; 971777
IARC_TP53; 27565
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number34