Cellosaurus logo
expasy logo

Cellosaurus C-4-II (CVCL_1095)

[Text version]
Cell line name C-4-II
Synonyms C-4 II; C-4II; C4 II; C4II
Accession CVCL_1095
Resource Identification Initiative To cite this cell line use: C-4-II (RRID:CVCL_1095)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
Population: Caucasian.
Virology: Contains a complete HPV18 genome.
Doubling time: 2.4 days (PubMed=29156801).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Omics: Deep exome analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related cervical squamous cell carcinoma (NCIt: C27676)
Squamous cell carcinoma of the cervix uteri (ORDO: Orphanet_213767)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_2253 ! C-4-I
Sex of cell Female
Age at sampling 41Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-1595; DepMap=ACH-001335; ECACC=88102701; PubMed=29156801

Markers:
AmelogeninX
CSF1PO12
D2S133823
D3S135816,17
D5S8189,11
D7S82010,11
D8S117914,15
D13S31711,12
D16S53911
D18S5114
D19S43313,14
D21S1129,30
FGA25
Penta D9,13
Penta E19
TH019,9.3
TPOX10,11
vWA14

Run an STR similarity search on this cell line
Publications

PubMed=13863218; DOI=10.1093/jnci/28.3.605
Auersperg N., Hawryluk A.P.
Chromosome observations on three epithelial-cell cultures derived from carcinomas of the human cervix.
J. Natl. Cancer Inst. 28:605-627(1962)

PubMed=14114965; DOI=10.1093/jnci/32.1.135
Auersperg N.
Long-term cultivation of hypodiploid human tumor cells.
J. Natl. Cancer Inst. 32:135-163(1964)

PubMed=5796380; DOI=10.1093/jnci/43.1.151
Auersperg N.
Histogenetic behavior of tumors. I. Morphologic variation in vitro and in vivo of two related human carcinoma cell lines.
J. Natl. Cancer Inst. 43:151-173(1969)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Fogh J., Wright W.C., Loveless J.D.
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=6935474; DOI=10.1093/jnci/66.2.239
Wright W.C., Daniels W.P., Fogh J.
Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis.
J. Natl. Cancer Inst. 66:239-247(1981)

PubMed=2990217; PMCID=PMC1888002
Yee C., Krishnan-Hewlett I., Baker C.C., Schlegel R., Howley P.M.
Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.
Am. J. Pathol. 119:361-366(1985)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=15531914; DOI=10.1038/sj.onc.1208235
Baldus S.E., Schwarz E., Lohrey C., Zapatka M., Landsberg S., Hahn S.A., Schmidt D., Dienes H.-P., Schmiegel W.H., Schwarte-Waldhoff I.
Smad4 deficiency in cervical carcinoma cells.
Oncogene 24:810-819(2005)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=24134916; DOI=10.1186/1755-8166-6-44; PMCID=PMC3879223
McCormack A., Fan J.-L., Duesberg M., Bloomfield M., Fiala C., Duesberg P.H.
Individual karyotypes at the origins of cervical carcinomas.
Mol. Cytogenet. 6:44.1-44.23(2013)

PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691
Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y., Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J., Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

PubMed=35692560; DOI=10.1080/23723556.2022.2078628; PMCID=PMC9176225
de Lourdes Zuniga-Martinez M., Lopez-Mendoza C.M., Tenorio-Salazar J., Garcia-Carranca A.M., Cerbon-Cervantes M.A., Alcantara-Quintana L.E.
Establishment, authenticity, and characterization of cervical cancer cell lines.
Mol. Cell. Oncol. 9:2078628.1-2078628.10(2022)

Cross-references
Cell line collections (Providers) ATCC; CRL-1595
ATCC; CRL-7914 - Discontinued
ECACC; 88102701
Cell line databases/resources CLO; CLO_0002126
CLDB; cl571
cancercelllines; CVCL_1095
Cell_Model_Passport; SIDM00906
DepMap; ACH-001335
IGRhCellID; C4II
LINCS_LDP; LCL-1302
Biological sample resources BioSample; SAMN03471403
Chemistry resources ChEMBL-Cells; CHEMBL3308712
ChEMBL-Targets; CHEMBL1075400
PubChem_Cell_line; CVCL_1095
Encyclopedic resources Wikidata; Q54799745
Experimental variables resources EFO; EFO_0002123
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
GEO; GSM675732
GEO; GSM685437
Polymorphism and mutation databases Cosmic; 760218
Cosmic; 809230
Cosmic; 910553
IARC_TP53; 21202
Progenetix; CVCL_1095
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number33