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Cellosaurus RPMI-4788 (CVCL_0U46)

[Text version]
Cell line name RPMI-4788
Synonyms RPMI 4788; RPMI4788; R.P.M.I. #4788; Roswell Park Memorial Institute 4788
Accession CVCL_0U46
Resource Identification Initiative To cite this cell line use: RPMI-4788 (RRID:CVCL_0U46)
Comments Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=23136038). Was originally thought to originate from the pleural fluid of a 73 year old female patient with a colon adenocarcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00387.
Population: African American.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): JCRB


Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx

Moore G.E., Mount D., Tara G., Schwartz N.
Growth of human tumor cells in suspension cultures.
Cancer Res. 23:1735-1741(1963)

Iwagaki H., Fuchimoto S., Shiiki S., Miyake M., Orita K.
Monitoring the effect of an anti-cancer drug on RPMI 4788 cells by a membrane potential probe, dis-C3-(5).
J. Med. 20:135-141(1989)

PubMed=23136038; DOI=10.1002/ijc.27931
Capes-Davis A., Reid Y.A., Kline M.C., Storts D.R., Strauss E., Dirks W.G., Drexler H.G., MacLeod R.A.F., Sykes G.R., Kohara A., Nakamura Y., Elmore E., Nims R.W., Alston-Roberts C., Barallon R., Los G.V., Nardone R.M., Price P.J., Steuer A., Thomson J.A., Masters J.R.W., Kerrigan L.
Match criteria for human cell line authentication: where do we draw the line?
Int. J. Cancer 132:2510-2519(2013)

Cell line collections (Providers) JCRB; JCRB1309 - Discontinued
JCRB; NIHS0553 - Discontinued
Biological sample resources BioSample; SAMN03151753
BioSample; SAMN03472398
Encyclopedic resources Wikidata; Q54951187
Entry history
Entry creation08-Jul-2015
Last entry update05-Oct-2023
Version number15