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Cellosaurus B-THP-1 (CVCL_0R19)

[Text version]
Cell line name B-THP-1
Accession CVCL_0R19
Resource Identification Initiative To cite this cell line use: B-THP-1 (RRID:CVCL_0R19)
Comments Problematic cell line: Misidentified. Originally thought to be THP-1 (PubMed=10721995) but later shown to be a derivative of Raji (PubMed=14972530).
Population: African; Nigerian.
Doubling time: ~20 hours (HIVReagentProgram=ARP-9940).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Bone, jaw, maxilla; UBERON=UBERON_0002397.
Sequence variations
  • Gene fusion; HGNC; 5477; IGH + HGNC; 7553; MYC; Name(s)=MYC-IGH (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg213Gln (c.638G>A); ClinVar=VCV000135359; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr234His (c.700T>C); ClinVar=VCV000376691; Zygosity=Heterozygous (from parent cell line).
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0511 (Raji)
Sex of cell Male
Age at sampling 11Y
Category Cancer cell line

PubMed=10721995; DOI=10.1016/S0092-8674(00)80694-7
Geijtenbeek T.B.H., Kwon D.S., Torensma R., van Vliet S.J., van Duijnhoven G.C.F., Middel J., Cornelissen I.L.M.H.A., Nottet H.S.L.M., KewalRamani V.N., Littman D.R., Figdor C.G., van Kooyk Y.
DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells.
Cell 100:587-597(2000)

PubMed=14972530; DOI=10.1016/j.virol.2003.09.028
Wu L., Martin T.D., Carrington M.N., KewalRamani V.N.
Raji B cells, misidentified as THP-1 cells, stimulate DC-SIGN-mediated HIV transmission.
Virology 318:17-23(2004)

Cell line collections (Providers) HIVReagentProgram; ARP-9940
Cell line databases/resources cancercelllines; CVCL_0R19
Encyclopedic resources Wikidata; Q54752139
Entry history
Entry creation08-Jul-2015
Last entry update05-Oct-2023
Version number18