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Cellosaurus S1-M1-80 (CVCL_0H87)

[Text version]
Cell line name S1-M1-80
Synonyms S1-MI-80; S1MI80
Accession CVCL_0H87
Resource Identification Initiative To cite this cell line use: S1-M1-80 (RRID:CVCL_0H87)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:50729; Mitoxantrone.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; 74; ABCG2; Simple; p.Arg482Gly (c.1444A>G); Zygosity=Unspecified (PubMed=11559526).
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0H86 (S1-M1-3.2)
Sex of cell Female
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=9892175
Miyake K., Mickley L.A., Litman T., Zhan Z.-R., Robey R.W., Cristensen B., Brangi M.F., Greenberger L.M., Dean M., Fojo T., Bates S.E.
Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes.
Cancer Res. 59:8-13(1999)

PubMed=11406094; DOI=10.1016/S0005-2736(01)00308-X
Robey R.W., Honjo Y., van de Laar A., Miyake K., Regis J.T., Litman T., Bates S.E.
A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2).
Biochim. Biophys. Acta 1512:171-182(2001)

PubMed=11559526
Honjo Y., Hrycyna C.A., Yan Q.-W., Medina-Perez W.Y., Robey R.W., van de Laar A., Litman T., Dean M., Bates S.E.
Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.
Cancer Res. 61:6635-6639(2001)

Cross-references
Cell line databases/resources cancercelllines; CVCL_0H87
Chemistry resources ChEMBL-Cells; CHEMBL4630712
ChEMBL-Targets; CHEMBL4630718
PubChem_Cell_line; CVCL_0H87
Encyclopedic resources Wikidata; Q54951790
Entry history
Entry creation10-Apr-2015
Last entry update05-Oct-2023
Version number14