ID   S1-M1-80
AC   CVCL_0H87
SY   S1-MI-80; S1MI80
DR   cancercelllines; CVCL_0H87
DR   ChEMBL-Cells; CHEMBL4630712
DR   ChEMBL-Targets; CHEMBL4630718
DR   PubChem_Cell_line; CVCL_0H87
DR   Wikidata; Q54951790
RX   PubMed=9892175;
RX   PubMed=11406094;
RX   PubMed=11559526;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:50729; Mitoxantrone.
CC   Sequence variation: Mutation; HGNC; 74; ABCG2; Simple; p.Arg482Gly (c.1444A>G); Zygosity=Unspecified (PubMed=11559526).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0H86 ! S1-M1-3.2
SX   Female
AG   58Y
CA   Cancer cell line
DT   Created: 10-04-15; Last updated: 05-10-23; Version: 14
//
RX   PubMed=9892175;
RA   Miyake K., Mickley L.A., Litman T., Zhan Z.-R., Robey R.W.,
RA   Cristensen B., Brangi M.F., Greenberger L.M., Dean M., Fojo T., Bates S.E.;
RT   "Molecular cloning of cDNAs which are highly overexpressed in
RT   mitoxantrone-resistant cells: demonstration of homology to ABC
RT   transport genes.";
RL   Cancer Res. 59:8-13(1999).
//
RX   PubMed=11406094; DOI=10.1016/S0005-2736(01)00308-X;
RA   Robey R.W., Honjo Y., van de Laar A., Miyake K., Regis J.T.,
RA   Litman T., Bates S.E.;
RT   "A functional assay for detection of the mitoxantrone resistance
RT   protein, MXR (ABCG2).";
RL   Biochim. Biophys. Acta 1512:171-182(2001).
//
RX   PubMed=11559526;
RA   Honjo Y., Hrycyna C.A., Yan Q.-W., Medina-Perez W.Y., Robey R.W.,
RA   van de Laar A., Litman T., Dean M., Bates S.E.;
RT   "Acquired mutations in the MXR/BCRP/ABCP gene alter substrate
RT   specificity in MXR/BCRP/ABCP-overexpressing cells.";
RL   Cancer Res. 61:6635-6639(2001).
//