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Cellosaurus AR42J-B13 (CVCL_0E02)

[Text version]
Cell line name AR42J-B13
Synonyms AR42J-B-13; B-13
Accession CVCL_0E02
Resource Identification Initiative To cite this cell line use: AR42J-B13 (RRID:CVCL_0E02)
Comments Characteristics: When exposed to glucocorticoid, trans-differentiates into hepatocyte-like (B-13/H) cells. B-13/H cells express a variety of liver-enriched and liver-specific genes, many at levels similar to hepatocytes in vivo.
Transformant: ChEBI; CHEBI_74846; Azaserine.
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Disease Rat digestive system neoplasms (NCIt: C60682)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: Wistar; RS=RS:0000955.
Hierarchy Parent: CVCL_0143 (AR42J)
Category Cancer cell line
Publications

PubMed=8756573; DOI=10.1210/endo.137.9.8756573
Mashima H., Shibata H., Mine T., Kojima I.
Formation of insulin-producing cells from pancreatic acinar AR42J cells by hepatocyte growth factor.
Endocrinology 137:3969-3976(1996)

PubMed=20685382; DOI=10.1016/j.tox.2010.05.008
Wallace K., Fairhall E.A., Charlton K.A., Wright M.C.
AR42J-B-13 cell: an expandable progenitor to generate an unlimited supply of functional hepatocytes.
Toxicology 278:277-287(2010)

DOI=10.1039/c4tx00214h
Probert P.M.E., Meyer S.K., Alsaeedi F., Axon A.A., Fairhall E.A., Wallace K., Charles M., Oakley F., Jowsey P.A., Blain P.G., Wright M.C.
An expandable donor-free supply of functional hepatocytes for toxicology.
Toxicol. Res. 4:203-222(2015)

Cross-references
Encyclopedic resources Wikidata; Q54750404
Entry history
Entry creation10-Apr-2015
Last entry update19-Dec-2024
Version number10