ID   AR42J-B13
AC   CVCL_0E02
SY   AR42J-B-13; B-13
DR   Wikidata; Q54750404
RX   DOI=10.1039/c4tx00214h;
RX   PubMed=8756573;
RX   PubMed=20685382;
CC   Characteristics: When exposed to glucocorticoid, trans-differentiates into hepatocyte-like (B-13/H) cells. B-13/H cells express a variety of liver-enriched and liver-specific genes, many at levels similar to hepatocytes in vivo.
CC   Transformant: ChEBI; CHEBI:74846; Azaserine.
CC   Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
CC   Breed/subspecies: Wistar; RS=RS:0000955.
DI   NCIt; C60682; Rat digestive system neoplasms
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
HI   CVCL_0143 ! AR42J
CA   Cancer cell line
DT   Created: 10-04-15; Last updated: 10-09-24; Version: 9
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RX   DOI=10.1039/c4tx00214h;
RA   Probert P.M.E., Meyer S.K., Alsaeedi F., Axon A.A., Fairhall E.A.,
RA   Wallace K., Charles M., Oakley F., Jowsey P.A., Blain P.G., Wright M.C.;
RT   "An expandable donor-free supply of functional hepatocytes for toxicology.";
RL   Toxicol. Res. 4:203-222(2015).
//
RX   PubMed=8756573; DOI=10.1210/endo.137.9.8756573;
RA   Mashima H., Shibata H., Mine T., Kojima I.;
RT   "Formation of insulin-producing cells from pancreatic acinar AR42J
RT   cells by hepatocyte growth factor.";
RL   Endocrinology 137:3969-3976(1996).
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RX   PubMed=20685382; DOI=10.1016/j.tox.2010.05.008;
RA   Wallace K., Fairhall E.A., Charlton K.A., Wright M.C.;
RT   "AR42J-B-13 cell: an expandable progenitor to generate an unlimited
RT   supply of functional hepatocytes.";
RL   Toxicology 278:277-287(2010).
//