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Cellosaurus DD-1 [Dog hemangiosarcoma] (CVCL_0C94)

[Text version]
Cell line name DD-1 [Dog hemangiosarcoma]
Synonyms DD1
Accession CVCL_0C94
Resource Identification Initiative To cite this cell line use: DD-1 [Dog hemangiosarcoma] (RRID:CVCL_0C94)
Comments Doubling time: 5-7 days (Kerafast=EMN009-FP).
Omics: Transcriptomics; Microarray.
Caution: Was incorrectly indicated to originate from a 9 year old dog (PubMed=19461996) but is in fact from a 11 year old dog (personal communication of Modiano, Jaime F. through Kerafast).
Derived from site: In situ; Spleen; UBERON=UBERON_0002106.
Disease Canine hemangiosarcoma (NCIt: C122783)
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Golden Retriever x Pyrenean mountain dog; VBO=VBO_0200610+VBO_0200629.
Sex of cell Male
Age at sampling 11Y
Category Cancer cell line
Publications

PubMed=15064773; DOI=10.1038/labinvest.3700080
Fosmire S.P., Dickerson E.B., Scott A.M., Bianco S.R., Pettengill M.J., Meylemans H.A., Padilla M.L., Frazer-Abel A.A., Akhtar N., Getzy D.M., Wojcieszyn J., Breen M., Helfand S.C., Modiano J.F.
Canine malignant hemangiosarcoma as a model of primitive angiogenic endothelium.
Lab. Invest. 84:562-572(2004)

PubMed=16797414; DOI=10.1016/j.exphem.2006.04.013
Lamerato-Kozicki A.R., Helm K.M., Jubala C.M., Cutter G.R., Modiano J.F.
Canine hemangiosarcoma originates from hematopoietic precursors with potential for endothelial differentiation.
Exp. Hematol. 34:870-878(2006)

PubMed=19461996; DOI=10.1371/journal.pone.0005549; PMCID=PMC2680013
Tamburini B.A., Trapp S., Phang T.L., Schappa J.T., Hunter L.E., Modiano J.F.
Gene expression profiles of sporadic canine hemangiosarcoma are uniquely associated with breed.
PLoS ONE 4:e5549.1-e5549.12(2009)

PubMed=24582862; DOI=10.1016/j.yexcr.2014.02.020; PMCID=PMC4256199
Kim J.-H., Frantz A.M., Anderson K.L., Graef A.J., Scott M.C., Robinson S., Sharkey L.C., O'Brien T.D., Dickerson E.B., Modiano J.F.
Interleukin-8 promotes canine hemangiosarcoma growth by regulating the tumor microenvironment.
Exp. Cell Res. 323:155-164(2014)

PubMed=30601866; DOI=10.1371/journal.pone.0210297; PMCID=PMC6314605
Dowling M., Samuelson J., Fadl-Alla B.A., Pondenis H.C., Byrum M., Barger A.M., Fan T.M.
Overexpression of prostate specific membrane antigen by canine hemangiosarcoma cells provides opportunity for the molecular detection of disease burdens within hemorrhagic body cavity effusions.
PLoS ONE 14:e0210297.1-e0210297.20(2019)

Cross-references
Cell line collections (Providers) Kerafast; EMN009-FP
Encyclopedic resources Wikidata; Q54828682
Gene expression databases GEO; GSM377407
GEO; GSM1122227
Entry history
Entry creation10-Apr-2015
Last entry update10-Apr-2025
Version number16