ID   DD-1 [Dog hemangiosarcoma]
AC   CVCL_0C94
SY   DD1
DR   GEO; GSM377407
DR   GEO; GSM1122227
DR   Kerafast; EMN009-FP
DR   Wikidata; Q54828682
RX   PubMed=15064773;
RX   PubMed=16797414;
RX   PubMed=19461996;
RX   PubMed=24582862;
RX   PubMed=30601866;
CC   Doubling time: 5-7 days (Kerafast=EMN009-FP).
CC   Omics: Transcriptomics; Microarray.
CC   Caution: Was incorrectly indicated to originate from a 9 year old dog (PubMed=19461996) but is in fact from a 11 year old dog (personal communication of Modiano, Jaime F. through Kerafast).
CC   Derived from site: In situ; Spleen; UBERON=UBERON_0002106.
CC   Breed/subspecies: Golden Retriever x Pyrenean mountain dog; VBO=VBO_0200610+VBO_0200629.
DI   NCIt; C122783; Canine hemangiosarcoma
OX   NCBI_TaxID=9615; ! Canis lupus familiaris (Dog)
SX   Male
AG   11Y
CA   Cancer cell line
DT   Created: 10-04-15; Last updated: 10-04-25; Version: 16
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RX   PubMed=15064773; DOI=10.1038/labinvest.3700080;
RA   Fosmire S.P., Dickerson E.B., Scott A.M., Bianco S.R.,
RA   Pettengill M.J., Meylemans H.A., Padilla M.L., Frazer-Abel A.A.,
RA   Akhtar N., Getzy D.M., Wojcieszyn J., Breen M., Helfand S.C.,
RA   Modiano J.F.;
RT   "Canine malignant hemangiosarcoma as a model of primitive angiogenic
RT   endothelium.";
RL   Lab. Invest. 84:562-572(2004).
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RX   PubMed=16797414; DOI=10.1016/j.exphem.2006.04.013;
RA   Lamerato-Kozicki A.R., Helm K.M., Jubala C.M., Cutter G.R.,
RA   Modiano J.F.;
RT   "Canine hemangiosarcoma originates from hematopoietic precursors with
RT   potential for endothelial differentiation.";
RL   Exp. Hematol. 34:870-878(2006).
//
RX   PubMed=19461996; DOI=10.1371/journal.pone.0005549; PMCID=PMC2680013;
RA   Tamburini B.A., Trapp S., Phang T.L., Schappa J.T., Hunter L.E.,
RA   Modiano J.F.;
RT   "Gene expression profiles of sporadic canine hemangiosarcoma are
RT   uniquely associated with breed.";
RL   PLoS ONE 4:e5549.1-e5549.12(2009).
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RX   PubMed=24582862; DOI=10.1016/j.yexcr.2014.02.020; PMCID=PMC4256199;
RA   Kim J.-H., Frantz A.M., Anderson K.L., Graef A.J., Scott M.C.,
RA   Robinson S., Sharkey L.C., O'Brien T.D., Dickerson E.B.,
RA   Modiano J.F.;
RT   "Interleukin-8 promotes canine hemangiosarcoma growth by regulating
RT   the tumor microenvironment.";
RL   Exp. Cell Res. 323:155-164(2014).
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RX   PubMed=30601866; DOI=10.1371/journal.pone.0210297; PMCID=PMC6314605;
RA   Dowling M., Samuelson J., Fadl-Alla B.A., Pondenis H.C., Byrum M.,
RA   Barger A.M., Fan T.M.;
RT   "Overexpression of prostate specific membrane antigen by canine
RT   hemangiosarcoma cells provides opportunity for the molecular detection
RT   of disease burdens within hemorrhagic body cavity effusions.";
RL   PLoS ONE 14:e0210297.1-e0210297.20(2019).
//