Cellosaurus WI-38 (CVCL_0579)
Cell line name | WI-38 | ||||||||||||||||||||||||||||||||||||||||||||||
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Synonyms | Wi-38; WI 38; WI38; Wistar Institute-38; AG06814E; AG06814G; AG06814H; AG06814-J; AG06814J; AG06814-M; AG06814-N | ||||||||||||||||||||||||||||||||||||||||||||||
Accession | CVCL_0579 | ||||||||||||||||||||||||||||||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: WI-38 (RRID:CVCL_0579) | ||||||||||||||||||||||||||||||||||||||||||||||
Comments | Group: Space-flown cell line (cellonaut). Group: Vaccine production cell line. Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982). Population: Caucasian; Swedish. Biotechnology: Used for the production of RA27/3 - the first rubella virus vaccine. Biotechnology: Used for the production of live oral adenovirus type 4 and type 7 vaccine used by the US military. Produced first by Wyeth Laboratories from 1971 to 1999 and from 2011 onward by Barr Pharmaceuticals. Biotechnology: Was used in the early 1970's for the production of the Human Diploid Cell Vaccine (HDCV) vaccine against rabies by Institut Merieux. Characteristics: Used in many context such as senescence and aging studies. Senescence: Life expectancy of 50 +- 10 population doublings. Senesces at 38 PDL (PubMed=17395773). Doubling time: ~24 hours (ATCC=CCL-75; ECACC=90020107). Omics: CTCF ChIP-seq epigenome analysis. Omics: miRNA expression profiling. Omics: SNP array analysis. Omics: Transcriptome analysis by microarray. Anecdotal: Hayflick when numbering diploid cell strains 'jumped' directly from WI-27 (which failed) to WI-38 (CelloPub=CLPUB00391). Anecdotal: Have been flown in space on Skylab-3 to study growth in microgravity (PubMed=352912). Derived from site: In situ; Fetal lung; UBERON=UBERON_0005597. Cell type: Fibroblast of lung; CL=CL_0002553. | ||||||||||||||||||||||||||||||||||||||||||||||
Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) | ||||||||||||||||||||||||||||||||||||||||||||||
Hierarchy | Children:
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Sex of cell | Female | ||||||||||||||||||||||||||||||||||||||||||||||
Age at sampling | 16FW | ||||||||||||||||||||||||||||||||||||||||||||||
Category | Finite cell line | ||||||||||||||||||||||||||||||||||||||||||||||
STR profile | Source(s): AddexBio=T0016037/5007; ATCC=CCL-75; CCRID; ECACC=90020107; JCRB=IFO50075; JCRB=JCRB9017; RCB=RCB0702; RCB=RCB0704; Technion Genomics Center Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||||||||||||||||||||||||||||||
Web pages | https://en.wikipedia.org/wiki/WI-38 https://www.ascb.org/activation-energy/the-story-of-wi-38-the-other-famous-cell-line/ http://www.bioedge.org/index.php/bioethics/bioethics_article/10637 http://www.slate.com/articles/technology/future_tense/2017/03/the_woman_whose_aborted_fetus_helped_create_the_rubella_vaccine.html http://www.aginginterventionfoundation.org/BookReview2.pdf | ||||||||||||||||||||||||||||||||||||||||||||||
Publications | PubMed=14064953; DOI=10.1164/arrd.1963.88.3P2.387 PubMed=14218592; DOI=10.4049/jimmunol.93.3.353 PubMed=5834207; DOI=10.1001/archpedi.1965.02090030401007 PubMed=14315085; DOI=10.1016/0014-4827(65)90211-9 PubMed=5956336; DOI=10.1038/210100a0 PubMed=5668122; DOI=10.3181/00379727-128-33119 PubMed=5347639; DOI=10.1016/0014-4827(69)90166-9 PubMed=5801069; DOI=10.1016/0027-5107(69)90054-2 DOI=10.1007/BF02618370 PubMed=4329447; DOI=10.1084/jem.133.3.454; PMCID=PMC2138946 PubMed=4695793; DOI=10.1007/BF02619060 PubMed=4203458 PubMed=4817727; DOI=10.1016/0014-4827(74)90416-9 PubMed=1031681 PubMed=17792436; DOI=10.1126/science.192.4235.125 PubMed=211143; DOI=10.1128/jcm.7.4.368-371.1978; PMCID=PMC274969 PubMed=352912; DOI=10.1007/BF02618218 PubMed=656543; DOI=10.1016/S0006-3495(78)85487-3; PMCID=PMC1473442 PubMed=699332; DOI=10.1016/0009-8981(78)90444-8 PubMed=535915; DOI=10.1007/BF02618249 PubMed=6256643; DOI=10.1038/288724a0 PubMed=7065527; DOI=10.1164/arrd.1982.125.2.222 PubMed=6409440; DOI=10.1093/carcin/4.7.911 PubMed=6887978; DOI=10.1016/0047-6374(83)90043-x DOI=10.1016/B978-0-12-007903-2.50014-3 PubMed=6538202; DOI=10.1083/jcb.98.3.1133; PMCID=PMC2113122 CLPUB00597 PubMed=7972006; DOI=10.1073/pnas.91.23.11045; PMCID=PMC45163 DOI=10.11418/jtca1981.16.3_147 PubMed=17395773; DOI=10.1634/stemcells.2006-0504 PubMed=19896956; DOI=10.1016/j.mrfmmm.2009.10.013 PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662 PubMed=22984048; DOI=10.1126/science.337.6100.1292-a DOI=10.1038/498407a DOI=10.1038/498422a PubMed=25063771; DOI=10.18632/aging.100679; PMCID=PMC4153623 PubMed=25903999; DOI=10.1002/biot.201400388 CLPUB00391 PubMed=29546209; DOI=10.3934/publichealth.2017.2.127; PMCID=PMC5689800 | ||||||||||||||||||||||||||||||||||||||||||||||
Cross-references | |||||||||||||||||||||||||||||||||||||||||||||||
Cell line collections (Providers) | AddexBio; T0016037/5007
ATCC; CCL-75 ATCC; CRL-7728 - Discontinued CCTCC; GDC0016 CLS; 300428 Coriell; AG06814-J Coriell; AG06814-M Coriell; AG06814-N ECACC; 90020107 IZSLER; BS CL 90 JCRB; IFO50075 JCRB; JCRB9017 - Discontinued KCB; KCB 200556YJ KCLB; 10075 - Discontinued RCB; RCB0702 RCB; RCB0704 TKG; TKG 0360 | ||||||||||||||||||||||||||||||||||||||||||||||
Cell line databases/resources | CLO; CLO_0009591
CLO; CLO_0009594 CLO; CLO_0035526 CLO; CLO_0035534 MCCL; MCC:0000485 CLDB; cl4703 CLDB; cl4704 CLDB; cl4705 cancercelllines; CVCL_0579 CCRID; 1101HUM-PUMC000210 CCRID; 1102HUM-NIFDC00067 CCRID; 3101HUMGNHu42 CCRID; 3101HUMSCSP521 CCRID; 4201HUM-CCTCC00016 IGRhCellID; WI38 Lonza; 495 | ||||||||||||||||||||||||||||||||||||||||||||||
Anatomy/cell type resources | BTO; BTO:0000458 | ||||||||||||||||||||||||||||||||||||||||||||||
Biological sample resources | BioSample; SAMN01821606
BioSample; SAMN01821721 BioSample; SAMN03471285 | ||||||||||||||||||||||||||||||||||||||||||||||
Chemistry resources | ChEMBL-Cells; CHEMBL3307614
ChEMBL-Cells; CHEMBL3307476 ChEMBL-Targets; CHEMBL614391 ChEMBL-Targets; CHEMBL612806 PubChem_Cell_line; CVCL_0579 | ||||||||||||||||||||||||||||||||||||||||||||||
Encyclopedic resources | Wikidata; Q7950532 | ||||||||||||||||||||||||||||||||||||||||||||||
Experimental variables resources | EFO; EFO_0001260 | ||||||||||||||||||||||||||||||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-38
GEO; GSE12450 GEO; GSE33710 GEO; GSM827323 GEO; GSM1022634 GEO; GSM1022637 GEO; GSM1022647 GEO; GSM1022655 | ||||||||||||||||||||||||||||||||||||||||||||||
Polymorphism and mutation databases | Progenetix; CVCL_0579 | ||||||||||||||||||||||||||||||||||||||||||||||
Entry history | |||||||||||||||||||||||||||||||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||||||||||||||||||||||||||||||
Last entry update | 10-Sep-2024 | ||||||||||||||||||||||||||||||||||||||||||||||
Version number | 42 |