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Cellosaurus UM-SCV-1A (CVCL_0568)

[Text version]
Cell line name UM-SCV-1A
Synonyms UMSCV-1A; UMSCV1A; University of Michigan-Squamous cell Carcinoma of the Vulva-1A
Accession CVCL_0568
Resource Identification Initiative To cite this cell line use: UM-SCV-1A (RRID:CVCL_0568)
Comments Doubling time: 32 hours (PubMed=15047230); 30.12 +- 0.43 hours (PubMed=31654625).
Derived from site: In situ; Vulva; UBERON=UBERON_0000997.
Sequence variations
Disease Vulvar squamous cell carcinoma (NCIt: C4052)
Vulvar squamous cell carcinoma (ORDO: Orphanet_494448)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_5973 ! UM-SCV-1B
Sex of cell Female
Age at sampling 62Y
Category Cancer cell line
Publications

PubMed=2758419
Pekkola-Heino K., Kulmala J., Grenman S.E., Carey T.E., Grenman R.
Radiation response of vulvar squamous cell carcinoma (UM-SCV-1A, UM-SCV-1B, UM-SCV-2, and A-431) cells in vitro.
Cancer Res. 49:4876-4878(1989)

PubMed=2335395; DOI=10.1002/ijc.2910450524
Grenman S.E., Van Dyke D.L., Worsham M.J., England B., McClatchey K.D., Hopkins M.P., Babu V.R., Grenman R., Carey T.E.
Phenotypic characterization, karyotype analysis and in vitro tamoxifen sensitivity of new ER-negative vulvar carcinoma cell lines, UM-SCV-1A and UM-SCV-1B.
Int. J. Cancer 45:920-927(1990)

PubMed=1777413; DOI=10.1002/gcc.2870030604
Worsham M.J., Van Dyke D.L., Grenman S.E., Grenman R., Hopkins M.P., Roberts J.A., Gasser K.M., Schwartz D.R., Carey T.E.
Consistent chromosome abnormalities in squamous cell carcinoma of the vulva.
Genes Chromosomes Cancer 3:420-432(1991)

PubMed=1958593; DOI=10.1002/gcc.2870030406
Bradford C.R., Kimmel K.A., Van Dyke D.L., Worsham M.J., Tilley B.J., Burk D., del Rosario F., Lutz S., Tooley R., Hayashida D.J.S., Carey T.E.
11p deletions and breakpoints in squamous cell carcinoma: association with altered reactivity with the UM-E7 antibody.
Genes Chromosomes Cancer 3:272-282(1991)

PubMed=7503188; DOI=10.1016/0002-9378(95)90636-3
Hietanen S.H., Kurvinen K., Syrjanen K.J., Grenman S.E., Carey T.E., McClatchey K.D., Syrjanen S.M.
Mutation of tumor suppressor gene p53 is frequently found in vulvar carcinoma cells.
Am. J. Obstet. Gynecol. 173:1477-1482(1995)

PubMed=7599042; DOI=10.1038/bjc.1995.289; PMCID=PMC2034151
Hietanen S.H., Grenman S.E., Syrjanen K.J., Lappalainen K., Kauppinen J., Carey T.E., Syrjanen S.M.
Human papillomavirus in vulvar and vaginal carcinoma cell lines.
Br. J. Cancer 72:134-139(1995)

PubMed=8646696; DOI=10.1002/(SICI)1097-0142(19960501)77:9<1940::AID-CNCR26>3.0.CO;2-Z
Jaakkola M., Rantanen V., Grenman S.E., Kulmala J., Grenman R.
In vitro concurrent paclitaxel and radiation of four vulvar squamous cell carcinoma cell lines.
Cancer 77:1940-1946(1996)

PubMed=9887230; DOI=10.1006/gyno.1998.5194
Rantanen V., Grenman S.E., Kurvinen K., Hietanen S.H., Raitanen M., Syrjanen S.M.
p53 mutations and presence of HPV DNA do not correlate with radiosensitivity of gynecological cancer cell lines.
Gynecol. Oncol. 71:352-358(1998)

CLPUB00591
Seppanen M.
Cytokines and gynecological cancer. In vitro effects of cytokines on ovarian, endometrial and vulvar carcinoma cells.
Thesis PhD (2000); Tampere University; Tampere; Finland

PubMed=15047230; DOI=10.1016/j.ygyno.2003.12.033
Raitanen M., Worsham M.J., Lakkala T., Carey T.E., Van Dyke D.L., Grenman R., Klemi P., Rantanen V., Isola J.J., Grenman S.E.
Characterization of 10 vulvar carcinoma cell lines by karyotyping, comparative genomic hybridization and flow cytometry.
Gynecol. Oncol. 93:155-163(2004)

PubMed=31654625; DOI=10.1016/j.yexcr.2019.111684
Dongre H.N., Rana N., Fromreide S., Rajthala S., Boe Engelsen I., Paradis J., Gutkind J.S., Vintermyr O.K., Johannessen A.C., Bjorge L., Costea D.E.
Establishment of a novel cancer cell line derived from vulvar carcinoma associated with lichen sclerosus exhibiting a fibroblast-dependent tumorigenic potential.
Exp. Cell Res. 386:111684.1-111684.9(2020)

Cross-references
Cell line databases/resources MCCL; MCC:0000473
Encyclopedic resources Wikidata; Q54990958
Polymorphism and mutation databases IARC_TP53; 21680
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number21