ID   UM-SCV-1A
AC   CVCL_0568
SY   UMSCV-1A; UMSCV1A; University of Michigan-Squamous cell Carcinoma of the Vulva-1A
DR   MCCL; MCC:0000473
DR   IARC_TP53; 21680
DR   Wikidata; Q54990958
RX   CelloPub=CLPUB00591;
RX   PubMed=1777413;
RX   PubMed=1958593;
RX   PubMed=2335395;
RX   PubMed=2758419;
RX   PubMed=7503188;
RX   PubMed=7599042;
RX   PubMed=8646696;
RX   PubMed=9887230;
RX   PubMed=15047230;
RX   PubMed=31654625;
CC   Doubling time: 32 hours (PubMed=15047230); 30.12 +- 0.43 hours (PubMed=31654625).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (PubMed=7503188; PubMed=9887230).
CC   Derived from site: In situ; Vulva; UBERON=UBERON_0000997.
DI   NCIt; C4052; Vulvar squamous cell carcinoma
DI   ORDO; Orphanet_494448; Vulvar squamous cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_5973 ! UM-SCV-1B
SX   Female
AG   62Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 21
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RX   CelloPub=CLPUB00591;
RA   Seppanen M.;
RT   "Cytokines and gynecological cancer. In vitro effects of cytokines on
RT   ovarian, endometrial and vulvar carcinoma cells.";
RL   Thesis PhD (2000); Tampere University; Tampere; Finland.
//
RX   PubMed=1777413; DOI=10.1002/gcc.2870030604;
RA   Worsham M.J., Van Dyke D.L., Grenman S.E., Grenman R., Hopkins M.P.,
RA   Roberts J.A., Gasser K.M., Schwartz D.R., Carey T.E.;
RT   "Consistent chromosome abnormalities in squamous cell carcinoma of the
RT   vulva.";
RL   Genes Chromosomes Cancer 3:420-432(1991).
//
RX   PubMed=1958593; DOI=10.1002/gcc.2870030406;
RA   Bradford C.R., Kimmel K.A., Van Dyke D.L., Worsham M.J., Tilley B.J.,
RA   Burk D., del Rosario F., Lutz S., Tooley R., Hayashida D.J.S.,
RA   Carey T.E.;
RT   "11p deletions and breakpoints in squamous cell carcinoma: association
RT   with altered reactivity with the UM-E7 antibody.";
RL   Genes Chromosomes Cancer 3:272-282(1991).
//
RX   PubMed=2335395; DOI=10.1002/ijc.2910450524;
RA   Grenman S.E., Van Dyke D.L., Worsham M.J., England B.,
RA   McClatchey K.D., Hopkins M.P., Babu V.R., Grenman R., Carey T.E.;
RT   "Phenotypic characterization, karyotype analysis and in vitro
RT   tamoxifen sensitivity of new ER-negative vulvar carcinoma cell lines,
RT   UM-SCV-1A and UM-SCV-1B.";
RL   Int. J. Cancer 45:920-927(1990).
//
RX   PubMed=2758419;
RA   Pekkola-Heino K., Kulmala J., Grenman S.E., Carey T.E., Grenman R.;
RT   "Radiation response of vulvar squamous cell carcinoma (UM-SCV-1A,
RT   UM-SCV-1B, UM-SCV-2, and A-431) cells in vitro.";
RL   Cancer Res. 49:4876-4878(1989).
//
RX   PubMed=7503188; DOI=10.1016/0002-9378(95)90636-3;
RA   Hietanen S.H., Kurvinen K., Syrjanen K.J., Grenman S.E., Carey T.E.,
RA   McClatchey K.D., Syrjanen S.M.;
RT   "Mutation of tumor suppressor gene p53 is frequently found in vulvar
RT   carcinoma cells.";
RL   Am. J. Obstet. Gynecol. 173:1477-1482(1995).
//
RX   PubMed=7599042; DOI=10.1038/bjc.1995.289; PMCID=PMC2034151;
RA   Hietanen S.H., Grenman S.E., Syrjanen K.J., Lappalainen K., Kauppinen J.,
RA   Carey T.E., Syrjanen S.M.;
RT   "Human papillomavirus in vulvar and vaginal carcinoma cell lines.";
RL   Br. J. Cancer 72:134-139(1995).
//
RX   PubMed=8646696; DOI=10.1002/(SICI)1097-0142(19960501)77:9<1940::AID-CNCR26>3.0.CO;2-Z;
RA   Jaakkola M., Rantanen V., Grenman S.E., Kulmala J., Grenman R.;
RT   "In vitro concurrent paclitaxel and radiation of four vulvar squamous
RT   cell carcinoma cell lines.";
RL   Cancer 77:1940-1946(1996).
//
RX   PubMed=9887230; DOI=10.1006/gyno.1998.5194;
RA   Rantanen V., Grenman S.E., Kurvinen K., Hietanen S.H., Raitanen M.,
RA   Syrjanen S.M.;
RT   "p53 mutations and presence of HPV DNA do not correlate with
RT   radiosensitivity of gynecological cancer cell lines.";
RL   Gynecol. Oncol. 71:352-358(1998).
//
RX   PubMed=15047230; DOI=10.1016/j.ygyno.2003.12.033;
RA   Raitanen M., Worsham M.J., Lakkala T., Carey T.E., Van Dyke D.L.,
RA   Grenman R., Klemi P., Rantanen V., Isola J.J., Grenman S.E.;
RT   "Characterization of 10 vulvar carcinoma cell lines by karyotyping,
RT   comparative genomic hybridization and flow cytometry.";
RL   Gynecol. Oncol. 93:155-163(2004).
//
RX   PubMed=31654625; DOI=10.1016/j.yexcr.2019.111684;
RA   Dongre H.N., Rana N., Fromreide S., Rajthala S., Boe Engelsen I.,
RA   Paradis J., Gutkind J.S., Vintermyr O.K., Johannessen A.C., Bjorge L.,
RA   Costea D.E.;
RT   "Establishment of a novel cancer cell line derived from vulvar
RT   carcinoma associated with lichen sclerosus exhibiting a
RT   fibroblast-dependent tumorigenic potential.";
RL   Exp. Cell Res. 386:111684.1-111684.9(2020).
//