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Cellosaurus IMIM-PC2 (CVCL_0345)

[Text version]
Cell line name IMIM-PC2
Synonyms IMIM-PC-2; IMIM PC-2; IMIMPC2; IM2; Instituto Municipal de Investigacion Medica-Pancreas Cancer 2
Accession CVCL_0345
Resource Identification Initiative To cite this cell line use: IMIM-PC2 (RRID:CVCL_0345)
Comments Doubling time: 33.6 hours (PubMed=7723277).
Karyotypic information: Has lost chromosome Y.
Omics: Transcriptome analysis by microarray.
Misspelling: IMM-PC2; Note=Occasionally.
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Sequence variations
HLA typing Source: PubMed=8795137
Class I
HLA-AA*25
HLA-BB*18
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=22585861

Markers:
AmelogeninX
CSF1PO11
D5S81812
D7S8208,10
D13S31711
D16S53911
TH017,9
TPOX8,11
vWA14,16

Run an STR similarity search on this cell line
Web pages http://dpsc.ccbr.utoronto.ca/cancer/get_cellline.pl?cellline=IMIM-PC-2
Publications

PubMed=8026879; DOI=10.1002/ijc.2910580207
Berrozpe G., Schaeffer J., Peinado M.A., Real F.X., Perucho M.
Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer.
Int. J. Cancer 58:185-191(1994)

PubMed=7723277
Vila M.R., Lloreta J., Schussler M.H., Berrozpe G., Welt S., Real F.X.
New pancreas cancers cell lines that represent distinct stages of ductal differentiation.
Lab. Invest. 72:395-404(1995)

PubMed=8795137; DOI=10.1111/j.1399-0039.1996.tb02572.x
Torres M.J., Ruiz-Cabello Osuna F., Skoudy A., Berrozpe G., Jimenez P., Serrano A., Real F.X., Garrido F.
Loss of an HLA haplotype in pancreas cancer tissue and its corresponding tumor derived cell line.
Tissue Antigens 47:372-381(1996)

PubMed=9665481; DOI=10.1016/S0002-9440(10)65561-7; PMCID=PMC1852940
Paciucci R., Vila M.R., Adell T., Diaz V.M., Tora M., Nakamura T., Real F.X.
Activation of the urokinase plasminogen activator/urokinase plasminogen activator receptor system and redistribution of E-cadherin are associated with hepatocyte growth factor-induced motility of pancreas tumor cells overexpressing Met.
Am. J. Pathol. 153:201-212(1998)

PubMed=11169957; DOI=10.1002/1097-0215(200002)9999:9999<::AID-IJC1014>3.0.CO;2-U
Wallrapp C., Hahnel S., Boeck W., Soder A., Mincheva A., Lichter P., Leder G., Gansauge F., Sorio C., Scarpa A., Gress T.M.
Loss of the Y chromosome is a frequent chromosomal imbalance in pancreatic cancer and allows differentiation to chronic pancreatitis.
Int. J. Cancer 91:340-344(2001)

PubMed=11787853; DOI=10.1007/s004280100474
Moore P.S., Sipos B., Orlandini S., Sorio C., Real F.X., Lemoine N.R., Gress T.M., Bassi C., Kloppel G., Kalthoff H., Ungefroren H., Lohr J.-M., Scarpa A.
Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4.
Virchows Arch. 439:798-802(2001)

PubMed=22585861; DOI=10.1158/2159-8290.CD-11-0224; PMCID=PMC5057396
Marcotte R., Brown K.R., Suarez Saiz F.J., Sayad A., Karamboulas K., Krzyzanowski P.M., Sircoulomb F., Medrano M., Fedyshyn Y., Koh J.L.-Y., van Dyk D., Fedyshyn B., Luhova M., Brito G.C., Vizeacoumar F.J., Vizeacoumar F.S., Datti A., Kasimer D., Buzina A., Mero P., Misquitta C., Normand J., Haider M., Ketela T., Wrana J.L., Rottapel R., Neel B.G., Moffat J.
Essential gene profiles in breast, pancreatic, and ovarian cancer cells.
Cancer Discov. 2:172-189(2012)

DOI=10.4172/2324-9293.1000104
Wagenhauser M.U., Ruckert F., Niedergethmann M., Grutzmann R., Saeger H.-D.
Distribution of characteristic mutations in native ductal adenocarcinoma of the pancreas and pancreatic cancer cell lines.
Cell Biol. Res. Ther. 2:1000104.1-1000104.5(2013)

Cross-references
Cell line databases/resources MCCL; MCC:0000241
cancercelllines; CVCL_0345
Encyclopedic resources Wikidata; Q54897589
Polymorphism and mutation databases Cosmic; 710859
Cosmic; 948728
IARC_TP53; 16741
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number21