ID   IMIM-PC2
AC   CVCL_0345
SY   IMIM-PC-2; IMIM PC-2; IMIMPC2; IM2; Instituto Municipal de Investigacion Medica-Pancreas Cancer 2
DR   MCCL; MCC:0000241
DR   cancercelllines; CVCL_0345
DR   Cosmic; 710859
DR   Cosmic; 948728
DR   IARC_TP53; 16741
DR   Wikidata; Q54897589
RX   DOI=10.4172/2324-9293.1000104;
RX   PubMed=7723277;
RX   PubMed=8026879;
RX   PubMed=8795137;
RX   PubMed=9665481;
RX   PubMed=11169957;
RX   PubMed=11787853;
RX   PubMed=22585861;
WW   http://dpsc.ccbr.utoronto.ca/cancer/get_cellline.pl?cellline=IMIM-PC-2
CC   Doubling time: 33.6 hours (PubMed=7723277).
CC   HLA typing: A*25; B*18 (PubMed=8795137).
CC   Karyotypic information: Has lost chromosome Y.
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=11787853).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (PubMed=8026879; PubMed=11787853).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Unspecified (PubMed=8026879; PubMed=11787853).
CC   Omics: Transcriptome analysis by microarray.
CC   Misspelling: IMM-PC2; Note=Occasionally.
CC   Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
ST   Source(s): PubMed=22585861
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 11
ST   D16S539: 11
ST   D5S818: 12
ST   D7S820: 8,10
ST   TH01: 7,9
ST   TPOX: 8,11
ST   vWA: 14,16
DI   NCIt; C9120; Pancreatic ductal adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 21
//
RX   DOI=10.4172/2324-9293.1000104;
RA   Wagenhauser M.U., Ruckert F., Niedergethmann M., Grutzmann R.,
RA   Saeger H.-D.;
RT   "Distribution of characteristic mutations in native ductal
RT   adenocarcinoma of the pancreas and pancreatic cancer cell lines.";
RL   Cell Biol. Res. Ther. 2:1000104.1-1000104.5(2013).
//
RX   PubMed=7723277;
RA   Vila M.R., Lloreta J., Schussler M.H., Berrozpe G., Welt S.,
RA   Real F.X.;
RT   "New pancreas cancers cell lines that represent distinct stages of
RT   ductal differentiation.";
RL   Lab. Invest. 72:395-404(1995).
//
RX   PubMed=8026879; DOI=10.1002/ijc.2910580207;
RA   Berrozpe G., Schaeffer J., Peinado M.A., Real F.X., Perucho M.;
RT   "Comparative analysis of mutations in the p53 and K-ras genes in
RT   pancreatic cancer.";
RL   Int. J. Cancer 58:185-191(1994).
//
RX   PubMed=8795137; DOI=10.1111/j.1399-0039.1996.tb02572.x;
RA   Torres M.J., Ruiz-Cabello Osuna F., Skoudy A., Berrozpe G., Jimenez P.,
RA   Serrano A., Real F.X., Garrido F.;
RT   "Loss of an HLA haplotype in pancreas cancer tissue and its
RT   corresponding tumor derived cell line.";
RL   Tissue Antigens 47:372-381(1996).
//
RX   PubMed=9665481; DOI=10.1016/S0002-9440(10)65561-7; PMCID=PMC1852940;
RA   Paciucci R., Vila M.R., Adell T., Diaz V.M., Tora M., Nakamura T.,
RA   Real F.X.;
RT   "Activation of the urokinase plasminogen activator/urokinase
RT   plasminogen activator receptor system and redistribution of E-cadherin
RT   are associated with hepatocyte growth factor-induced motility of
RT   pancreas tumor cells overexpressing Met.";
RL   Am. J. Pathol. 153:201-212(1998).
//
RX   PubMed=11169957; DOI=10.1002/1097-0215(200002)9999:9999<::AID-IJC1014>3.0.CO;2-U;
RA   Wallrapp C., Hahnel S., Boeck W., Soder A., Mincheva A., Lichter P.,
RA   Leder G., Gansauge F., Sorio C., Scarpa A., Gress T.M.;
RT   "Loss of the Y chromosome is a frequent chromosomal imbalance in
RT   pancreatic cancer and allows differentiation to chronic
RT   pancreatitis.";
RL   Int. J. Cancer 91:340-344(2001).
//
RX   PubMed=11787853; DOI=10.1007/s004280100474;
RA   Moore P.S., Sipos B., Orlandini S., Sorio C., Real F.X., Lemoine N.R.,
RA   Gress T.M., Bassi C., Kloppel G., Kalthoff H., Ungefroren H.,
RA   Lohr J.-M., Scarpa A.;
RT   "Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras,
RT   p53, p16 and DPC4/Smad4.";
RL   Virchows Arch. 439:798-802(2001).
//
RX   PubMed=22585861; DOI=10.1158/2159-8290.CD-11-0224; PMCID=PMC5057396;
RA   Marcotte R., Brown K.R., Suarez Saiz F.J., Sayad A., Karamboulas K.,
RA   Krzyzanowski P.M., Sircoulomb F., Medrano M., Fedyshyn Y., Koh J.L.-Y.,
RA   van Dyk D., Fedyshyn B., Luhova M., Brito G.C., Vizeacoumar F.J.,
RA   Vizeacoumar F.S., Datti A., Kasimer D., Buzina A., Mero P.,
RA   Misquitta C., Normand J., Haider M., Ketela T., Wrana J.L.,
RA   Rottapel R., Neel B.G., Moffat J.;
RT   "Essential gene profiles in breast, pancreatic, and ovarian cancer
RT   cells.";
RL   Cancer Discov. 2:172-189(2012).
//