Cellosaurus cell line HSC-T6 (CVCL

Cellosaurus HSC-T6 (CVCL_0315)

Cross-references
Cell line name	HSC-T6
Synonyms	HSCT6
Accession	CVCL_0315
Resource Identification Initiative	To cite this cell line use: HSC-T6 (RRID:CVCL_0315)
Comments	Doubling time: 10 hours (PubMed=26300973). Karyotypic information: 43,XX,der(1),+4,+7,-12,+mar (PubMed=35681478). Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40). Omics: Transcriptomics; RNAseq. Caution: Was originally (PubMed=10828080) reported to be established from a male rat, but was later shown (PubMed=35681478) to have a female karyotype. Derived from site: In situ; Liver; UBERON=UBERON_0002107. Cell type: Hepatic stellate cell; CL=CL_0000632.
Species of origin	Rattus norvegicus (Rat) (NCBI Taxonomy: 10116) Breed/subspecies: Sprague Dawley; RS=RS_0000681.
Sex of cell	Female
Age at sampling	Adult
Category	Transformed cell line
Publications	PubMed=10828080; DOI=10.1016/S0022-2275(20)32030-7 Vogel S., Piantedosi R., Frank J., Lalazar A., Rockey D.C., Friedman S.L., Blaner W.S. An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro. J. Lipid Res. 41:882-893(2000) PubMed=17760834; DOI=10.1111/j.1582-4934.2007.00060.x; PMCID=PMC3823251 Herrmann J., Gressner A.M., Weiskirchen R. Immortal hepatic stellate cell lines: useful tools to study hepatic stellate cell biology and function? J. Cell. Mol. Med. 11:704-722(2007) PubMed=26300973; DOI=10.1186/s13069-015-0032-y; PMCID=PMC4546255 Stone L.C., Thorne L.S., Weston C.J., Graham M., Hodges N.J. Cytoglobin expression in the hepatic stellate cell line HSC-T6 is regulated by extracellular matrix proteins dependent on FAK-signalling. Fibrogenesis Tissue Repair 8:15.1-15.15(2015) PubMed=35681478; DOI=10.3390/cells11111783; PMCID=PMC9179542 Nanda I., Steinlein C., Haaf T., Buhl E.M., Grimm D.G., Friedman S.L., Meurer S.K., Schroder S.K., Weiskirchen R. Genetic characterization of rat hepatic stellate cell line HSC-T6 for in vitro cell line authentication. Cells 11:1783.1-1783.21(2022)
Cell line collections (Providers)	CLS; 305199 KCB; KCB 200703YJ Millipore; SCC069
Cell line databases/resources	MCCL; MCC:0000208
Anatomy/cell type resources	BTO; BTO_0003520
Chemistry resources	ChEMBL-Cells; CHEMBL4651377 PubChem_Cell_line; CVCL_0315
Encyclopedic resources	Wikidata; Q54896418
Entry history
Entry creation	04-Apr-2012
Last entry update	10-Apr-2025
Version number	20