ID   HSC-T6
AC   CVCL_0315
SY   HSCT6
DR   BTO; BTO_0003520
DR   MCCL; MCC:0000208
DR   ChEMBL-Cells; CHEMBL4651377
DR   CLS; 305199
DR   KCB; KCB 200703YJ
DR   Millipore; SCC069
DR   PubChem_Cell_line; CVCL_0315
DR   Wikidata; Q54896418
RX   PubMed=10828080;
RX   PubMed=17760834;
RX   PubMed=26300973;
RX   PubMed=35681478;
CC   Doubling time: 10 hours (PubMed=26300973).
CC   Karyotypic information: 43,XX,der(1),+4,+7,-12,+mar (PubMed=35681478).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Omics: Transcriptome analysis by RNAseq.
CC   Caution: Was originally (PubMed=10828080) reported to be established from a male rat, but was later shown (PubMed=35681478) to have a female karyotype.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
CC   Cell type: Hepatic stellate cell; CL=CL_0000632.
CC   Breed/subspecies: Sprague Dawley; RS=RS:0000681.
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
SX   Female
AG   Adult
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 19
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RX   PubMed=10828080; DOI=10.1016/S0022-2275(20)32030-7;
RA   Vogel S., Piantedosi R., Frank J., Lalazar A., Rockey D.C.,
RA   Friedman S.L., Blaner W.S.;
RT   "An immortalized rat liver stellate cell line (HSC-T6): a new cell
RT   model for the study of retinoid metabolism in vitro.";
RL   J. Lipid Res. 41:882-893(2000).
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RX   PubMed=17760834; DOI=10.1111/j.1582-4934.2007.00060.x; PMCID=PMC3823251;
RA   Herrmann J., Gressner A.M., Weiskirchen R.;
RT   "Immortal hepatic stellate cell lines: useful tools to study hepatic
RT   stellate cell biology and function?";
RL   J. Cell. Mol. Med. 11:704-722(2007).
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RX   PubMed=26300973; DOI=10.1186/s13069-015-0032-y; PMCID=PMC4546255;
RA   Stone L.C., Thorne L.S., Weston C.J., Graham M., Hodges N.J.;
RT   "Cytoglobin expression in the hepatic stellate cell line HSC-T6 is
RT   regulated by extracellular matrix proteins dependent on
RT   FAK-signalling.";
RL   Fibrogenesis Tissue Repair 8:15.1-15.15(2015).
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RX   PubMed=35681478; DOI=10.3390/cells11111783; PMCID=PMC9179542;
RA   Nanda I., Steinlein C., Haaf T., Buhl E.M., Grimm D.G., Friedman S.L.,
RA   Meurer S.K., Schroder S.K., Weiskirchen R.;
RT   "Genetic characterization of rat hepatic stellate cell line HSC-T6 for
RT   in vitro cell line authentication.";
RL   Cells 11:1783.1-1783.21(2022).
//