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Cellosaurus HL-60/ADR (CVCL_0304)

[Text version]
Cell line name HL-60/ADR
Synonyms HL60/ADR; HL60/Adr; HL60-ADR
Accession CVCL_0304
Resource Identification Initiative To cite this cell line use: HL-60/ADR (RRID:CVCL_0304)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; 11998; TP53; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0002 (HL-60)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
Publications

PubMed=2425939
Marsh W., Sicheri D., Center M.S.
Isolation and characterization of adriamycin-resistant HL-60 cells which are not defective in the initial intracellular accumulation of drug.
Cancer Res. 46:4053-4057(1986)

PubMed=2886122; DOI=10.1016/0006-291X(87)91560-9
McGrath T., Center M.S.
Adriamycin resistance in HL60 cells in the absence of detectable P-glycoprotein.
Biochem. Biophys. Res. Commun. 145:1171-1176(1987)

PubMed=2573357; DOI=10.1016/0006-2952(89)90134-2
McGrath T., Latoud C., Arnold S.T., Safa A.R., Felsted R.L., Center M.S.
Mechanisms of multidrug resistance in HL60 cells. Analysis of resistance associated membrane proteins and levels of mdr gene expression.
Biochem. Pharmacol. 38:3611-3619(1989)

Cross-references
Cell line databases/resources MCCL; MCC:0000196
cancercelllines; CVCL_0304
Anatomy/cell type resources BTO; BTO:0003572
Chemistry resources ChEMBL-Cells; CHEMBL3833762
ChEMBL-Targets; CHEMBL4296430
PubChem_Cell_line; CVCL_0304
Encyclopedic resources Wikidata; Q54889800
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number24