ID   HL-60/ADR
AC   CVCL_0304
SY   HL60/ADR; HL60/Adr; HL60-ADR
DR   BTO; BTO:0003572
DR   MCCL; MCC:0000196
DR   cancercelllines; CVCL_0304
DR   ChEMBL-Cells; CHEMBL3833762
DR   ChEMBL-Targets; CHEMBL4296430
DR   PubChem_Cell_line; CVCL_0304
DR   Wikidata; Q54889800
RX   PubMed=2425939;
RX   PubMed=2573357;
RX   PubMed=2886122;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
CC   Sequence variation: Gene deletion; HGNC; 11998; TP53; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9154; Adult acute myeloid leukemia
DI   ORDO; Orphanet_519; Acute myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0002 ! HL-60
SX   Female
AG   36Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 24
//
RX   PubMed=2425939;
RA   Marsh W., Sicheri D., Center M.S.;
RT   "Isolation and characterization of adriamycin-resistant HL-60 cells
RT   which are not defective in the initial intracellular accumulation of
RT   drug.";
RL   Cancer Res. 46:4053-4057(1986).
//
RX   PubMed=2573357; DOI=10.1016/0006-2952(89)90134-2;
RA   McGrath T., Latoud C., Arnold S.T., Safa A.R., Felsted R.L.,
RA   Center M.S.;
RT   "Mechanisms of multidrug resistance in HL60 cells. Analysis of
RT   resistance associated membrane proteins and levels of mdr gene
RT   expression.";
RL   Biochem. Pharmacol. 38:3611-3619(1989).
//
RX   PubMed=2886122; DOI=10.1016/0006-291X(87)91560-9;
RA   McGrath T., Center M.S.;
RT   "Adriamycin resistance in HL60 cells in the absence of detectable
RT   P-glycoprotein.";
RL   Biochem. Biophys. Res. Commun. 145:1171-1176(1987).
//