Cellosaurus cell line Beta-TC-3 (CVCL

Cellosaurus Beta-TC-3 (CVCL_0172)

Cross-references
Cell line name	Beta-TC-3
Synonyms	beta-TC-3; beta-TC3; beta TC3; BETA-TC-3; BETATC3; BetaTC3; betaTC3; bTC3
Accession	CVCL_0172
Resource Identification Initiative	To cite this cell line use: Beta-TC-3 (RRID:CVCL_0172)
Comments	Doubling time: ~34 hours (DSMZ=ACC-324). Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; SV40 large T antigen. Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40). Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006. Cell type: Pancreatic beta cell; CL=CL_0000169.
Disease	Mouse insulinoma (NCIt: C34053)
Species of origin	Mus musculus (Mouse) (NCBI Taxonomy: 10090) Breed/subspecies: (C57BL/6J x DBA/2J)F2 transgenic RIPTag2.
Category	Transformed cell line
Web pages	https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/b/cell-lines-detail-210.html
Publications	PubMed=2848253; DOI=10.1073/pnas.85.23.9037; PMCID=PMC282658 Efrat S., Linde S., Kofod H., Spector D.L., Delannoy M., Grant S.G.N., Hanahan D., Baekkeskov S. Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene. Proc. Natl. Acad. Sci. U.S.A. 85:9037-9041(1988) PubMed=1710218; DOI=10.1016/S0021-9258(18)99139-8 Efrat S., Surana M., Fleischer N. Glucose induces insulin gene transcription in a murine pancreatic beta-cell line. J. Biol. Chem. 266:11141-11143(1991) PubMed=22538498; DOI=10.1159/000338793 Grozinsky-Glasberg S., Shimon I., Rubinfeld H. The role of cell lines in the study of neuroendocrine tumors. Neuroendocrinology 96:173-187(2012)
Cell line collections (Providers)	DSMZ; ACC-324 IBRC; C10109
Cell line databases/resources	CLO; CLO_0001932 MCCL; MCC:0000063 DSMZCellDive; ACC-324 TOKU-E; 4054
Anatomy/cell type resources	BTO; BTO_0002993
Chemistry resources	ChEMBL-Cells; CHEMBL3308357 ChEMBL-Targets; CHEMBL614063 PubChem_Cell_line; CVCL_0172
Encyclopedic resources	Wikidata; Q54796097
Entry history
Entry creation	04-Apr-2012
Last entry update	19-Dec-2024
Version number	22