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Cellosaurus MC3 (CVCL_0087)

[Text version]
Cell line name MC3
Synonyms MC-3
Accession CVCL_0087
Resource Identification Initiative To cite this cell line use: MC3 (RRID:CVCL_0087)
Comments Population: Japanese.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 50Y
Category Cancer cell line
Publications

PubMed=1884023; DOI=10.1182/blood.V78.6.1574.1574
Okabe M., Kunieda Y., Sugiwura T., Tanaka M., Miyagishima T., Saiki I., Minagawa T., Kurosawa M., Itaya T., Miyazaki T.
Inhibitory effect of interleukin-4 on the in vitro growth of Ph1-positive acute lymphoblastic leukemia cells.
Blood 78:1574-1580(1991)

PubMed=7787756; DOI=10.3109/10428199509054439
Okabe M., Kunieda Y., Nakane S., Kurosawa M., Itaya T., Vogler W.R., Shoji M., Miyazaki T.
Establishment and characterization of a new Ph1-positive chronic myeloid leukemia cell line MC3 with trilineage phenotype and an altered p53 gene.
Leuk. Lymphoma 16:493-503(1995)

PubMed=8632663; DOI=10.1016/0145-2126(95)00039-9
Okabe M., Kunieda Y., Shoji M., Nakane S., Kurosawa M., Tanaka J., Hansen S.R., Asaka M.
Megakaryocytic differentiation of a leukemic cell line, MC3, by phorbol ester: induction of glycoprotein IIb/IIIa and effects on expression of IL-6, IL-6 receptor, mpl and GATA genes.
Leuk. Res. 19:933-943(1995)

PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4
Drexler H.G., MacLeod R.A.F., Uphoff C.C.
Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.
Leuk. Res. 23:207-215(1999)

PubMed=10576511; DOI=10.1016/S0145-2126(99)00131-9
Uphoff C.C., Habig S., Fombonne S., Matsuo Y., Drexler H.G.
ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.
Leuk. Res. 23:1055-1060(1999)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=20809971; DOI=10.1186/1755-8166-3-15; PMCID=PMC2944125
Virgili A., Nacheva E.
Genomic amplification of BCR/ABL1 and a region downstream of ABL1 in chronic myeloid leukaemia: a FISH mapping study of CML patients and cell lines.
Mol. Cytogenet. 3:15.1-15.12(2010)

Cross-references
Cell line databases/resources CLO; CLO_0007581
Encyclopedic resources Wikidata; Q54904196
Polymorphism and mutation databases Cosmic; 787502
Cosmic; 1012085
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number19