ID   MC3
AC   CVCL_0087
SY   MC-3
DR   CLO; CLO_0007581
DR   Cosmic; 787502
DR   Cosmic; 1012085
DR   Wikidata; Q54904196
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=1884023;
RX   PubMed=7787756;
RX   PubMed=8632663;
RX   PubMed=10071072;
RX   PubMed=10576511;
RX   PubMed=16408098;
RX   PubMed=20809971;
CC   Population: Japanese.
CC   Sequence variation: Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (PubMed=7787756; PubMed=10071072; PubMed=10576511; PubMed=20809971).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C3174; Chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   50Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 19
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=1884023; DOI=10.1182/blood.V78.6.1574.1574;
RA   Okabe M., Kunieda Y., Sugiwura T., Tanaka M., Miyagishima T., Saiki I.,
RA   Minagawa T., Kurosawa M., Itaya T., Miyazaki T.;
RT   "Inhibitory effect of interleukin-4 on the in vitro growth of
RT   Ph1-positive acute lymphoblastic leukemia cells.";
RL   Blood 78:1574-1580(1991).
//
RX   PubMed=7787756; DOI=10.3109/10428199509054439;
RA   Okabe M., Kunieda Y., Nakane S., Kurosawa M., Itaya T., Vogler W.R.,
RA   Shoji M., Miyazaki T.;
RT   "Establishment and characterization of a new Ph1-positive chronic
RT   myeloid leukemia cell line MC3 with trilineage phenotype and an
RT   altered p53 gene.";
RL   Leuk. Lymphoma 16:493-503(1995).
//
RX   PubMed=8632663; DOI=10.1016/0145-2126(95)00039-9;
RA   Okabe M., Kunieda Y., Shoji M., Nakane S., Kurosawa M., Tanaka J.,
RA   Hansen S.R., Asaka M.;
RT   "Megakaryocytic differentiation of a leukemic cell line, MC3, by
RT   phorbol ester: induction of glycoprotein IIb/IIIa and effects on
RT   expression of IL-6, IL-6 receptor, mpl and GATA genes.";
RL   Leuk. Res. 19:933-943(1995).
//
RX   PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4;
RA   Drexler H.G., MacLeod R.A.F., Uphoff C.C.;
RT   "Leukemia cell lines: in vitro models for the study of Philadelphia
RT   chromosome-positive leukemia.";
RL   Leuk. Res. 23:207-215(1999).
//
RX   PubMed=10576511; DOI=10.1016/S0145-2126(99)00131-9;
RA   Uphoff C.C., Habig S., Fombonne S., Matsuo Y., Drexler H.G.;
RT   "ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.";
RL   Leuk. Res. 23:1055-1060(1999).
//
RX   PubMed=16408098; DOI=10.1038/sj.leu.2404081;
RA   Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.;
RT   "JAK2 V617F tyrosine kinase mutation in cell lines derived from
RT   myeloproliferative disorders.";
RL   Leukemia 20:471-476(2006).
//
RX   PubMed=20809971; DOI=10.1186/1755-8166-3-15; PMCID=PMC2944125;
RA   Virgili A., Nacheva E.;
RT   "Genomic amplification of BCR/ABL1 and a region downstream of ABL1 in
RT   chronic myeloid leukaemia: a FISH mapping study of CML patients and
RT   cell lines.";
RL   Mol. Cytogenet. 3:15.1-15.12(2010).
//