Cellosaurus SiHa (CVCL_0032)
Cell line name | SiHa | ||||||||||||||||||||||||||||||||||||
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Synonyms | Siha; SIHA | ||||||||||||||||||||||||||||||||||||
Accession | CVCL_0032 | ||||||||||||||||||||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: SiHa (RRID:CVCL_0032) | ||||||||||||||||||||||||||||||||||||
Comments | Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). Part of: COSMIC cell lines project. Population: Japanese. Virology: Contains a complete HPV16 genome with a disruption of the E2 region and a small deletion (PubMed=24201445). Doubling time: 2.6 days (PubMed=29156801); 17 hours (Note=In 10% FBS), 21 hours (Note=In 5% FBS) (PubMed=30760827). Microsatellite instability: Stable (MSS) (Sanger). Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16). Omics: CNV analysis. Omics: Deep antibody staining analysis. Omics: Deep exome analysis. Omics: Deep quantitative proteome analysis. Omics: DNA methylation analysis. Omics: Protein expression by reverse-phase protein arrays. Omics: Secretome proteome analysis by 2D-DE/MS. Omics: SNP array analysis. Omics: Transcriptome analysis by microarray. Omics: Transcriptome analysis by RNAseq. Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002. | ||||||||||||||||||||||||||||||||||||
HLA typing | Source: PubMed=26589293
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Genome ancestry | Source: PubMed=30894373
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Disease | Human papillomavirus-related cervical squamous cell carcinoma (NCIt: C27676) Squamous cell carcinoma of the cervix uteri (ORDO: Orphanet_213767) | ||||||||||||||||||||||||||||||||||||
Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) | ||||||||||||||||||||||||||||||||||||
Hierarchy | Children:
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Sex of cell | Female | ||||||||||||||||||||||||||||||||||||
Age at sampling | 55Y | ||||||||||||||||||||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||||||||||||||||||||
STR profile | Source(s): AddexBio=C0008002/372; ATCC=HTB-35; CCRID; Cosmic-CLP=930297; KCLB=30035; PubMed=25877200; PubMed=29156801 Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||||||||||||||||||||
Web pages | https://www.proteinatlas.org/learn/cellines https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/s/cell-lines-detail-22.html | ||||||||||||||||||||||||||||||||||||
Publications | PubMed=5529598; DOI=10.3181/00379727-135-35091a PubMed=327080; DOI=10.1093/jnci/59.1.221 PubMed=833871; DOI=10.1093/jnci/58.2.209 PubMed=2990217; PMCID=PMC1888002 PubMed=3518877; DOI=10.3109/07357908609038260 PubMed=3029430; DOI=10.1128/JVI.61.4.962-971.1987; PMCID=PMC254051 PubMed=3029760; DOI=10.1073/pnas.84.4.1070; PMCID=PMC304363 PubMed=1394225 PubMed=10423141; DOI=10.1099/0022-1317-80-7-1725 PubMed=15531914; DOI=10.1038/sj.onc.1208235 PubMed=17311676; DOI=10.1186/1471-2164-8-53; PMCID=PMC1805756 PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113 PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662 PubMed=20429727; DOI=10.3109/02841861003614343 PubMed=21439369; DOI=10.1016/j.mcp.2011.03.003 PubMed=22412903; DOI=10.1371/journal.pone.0032667; PMCID=PMC3296745 PubMed=24134916; DOI=10.1186/1755-8166-6-44; PMCID=PMC3879223 PubMed=23881600; DOI=10.1002/jcp.24433 PubMed=24201445; DOI=10.1101/gr.164806.113; PMCID=PMC3912410 PubMed=25485619; DOI=10.1038/nbt.3080 PubMed=25877200; DOI=10.1038/nature14397 PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878 PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469 PubMed=28261610; DOI=10.1155/2017/4180703; PMCID=PMC5316418 PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691 PubMed=30760827; DOI=10.1038/s41598-018-38315-7; PMCID=PMC6374403 PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675 PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103 PubMed=35198691; DOI=10.1016/j.dib.2022.107919; PMCID=PMC8844217 PubMed=35421932; DOI=10.1186/s12885-022-09528-x; PMCID=PMC9009492 PubMed=35692560; DOI=10.1080/23723556.2022.2078628; PMCID=PMC9176225 PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775 | ||||||||||||||||||||||||||||||||||||
Cross-references | |||||||||||||||||||||||||||||||||||||
Cell line collections (Providers) | AddexBio; C0008002/372
ATCC; HTB-35 CCTCC; GDC0110 CLS; 305023 ICLC; HTL98017 IZSLER; BS TCL 112 KCB; KCB 2013026YJ KCLB; 30035 | ||||||||||||||||||||||||||||||||||||
Cell line databases/resources | CLO; CLO_0009017
MCCL; MCC:0000451 CLDB; cl4298 CLDB; cl4299 CLDB; cl4900 cancercelllines; CVCL_0032 CCRID; 1101HUM-PUMC000294 CCRID; 1102HUM-NIFDC00092 CCRID; 3101HUMSCSP5058 CCRID; 3101HUMTCHu113 CCRID; 4201HUM-CCTCC00110 Cell_Model_Passport; SIDM01093 Cosmic-CLP; 930297 DepMap; ACH-000556 IGRhCellID; SiHa LINCS_LDP; LCL-1542 TOKU-E; 3119 | ||||||||||||||||||||||||||||||||||||
Anatomy/cell type resources | BTO; BTO:0002210 | ||||||||||||||||||||||||||||||||||||
Biological sample resources | BioSample; SAMN03473215
BioSample; SAMN10989623 | ||||||||||||||||||||||||||||||||||||
CRISP screens repositories | BioGRID_ORCS_Cell_line; 1796 | ||||||||||||||||||||||||||||||||||||
Chemistry resources | ChEMBL-Cells; CHEMBL3307968
ChEMBL-Targets; CHEMBL612542 GDSC; 930297 PharmacoDB; SiHa_1377_2019 PubChem_Cell_line; CVCL_0032 | ||||||||||||||||||||||||||||||||||||
Encyclopedic resources | Wikidata; Q54953470 | ||||||||||||||||||||||||||||||||||||
Experimental variables resources | EFO; EFO_0002379 | ||||||||||||||||||||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783 ArrayExpress; E-MTAB-2706 ArrayExpress; E-MTAB-3610 GEO; GSM113866 GEO; GSM226740 GEO; GSM226876 GEO; GSM253302 GEO; GSM675738 GEO; GSM685444 GEO; GSM722576 GEO; GSM722577 GEO; GSM723057 GEO; GSM723058 GEO; GSM1670422 GEO; GSM1716411 GEO; GSM1716412 GEO; GSM1716413 GEO; GSM1716414 GEO; GSM1716415 GEO; GSM1716416 GEO; GSM1716423 GEO; GSM1716424 GEO; GSM1716425 GEO; GSM1716426 | ||||||||||||||||||||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 760220
Cosmic; 809229 Cosmic; 846184 Cosmic; 877467 Cosmic; 925356 Cosmic; 928911 Cosmic; 930297 Cosmic; 1019306 Cosmic; 1131517 Cosmic; 1193028 Cosmic; 1201773 Cosmic; 1324212 Cosmic; 1995627 Cosmic; 2301542 Cosmic; 2660193 Cosmic; 2791018 Cosmic; 2816217 IARC_TP53; 21696 Progenetix; CVCL_0032 | ||||||||||||||||||||||||||||||||||||
Proteomic databases | PRIDE; PXD001806
PRIDE; PXD005466 PRIDE; PXD029773 PRIDE; PXD030304 PRIDE; PXD030885 | ||||||||||||||||||||||||||||||||||||
Sequence databases | EGA; EGAS00001000610
EGA; EGAS00001000978 | ||||||||||||||||||||||||||||||||||||
Entry history | |||||||||||||||||||||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||||||||||||||||||||
Last entry update | 02-May-2024 | ||||||||||||||||||||||||||||||||||||
Version number | 44 |