Molecular Cytogenetics of Common Epithelial Cancers > Pancreatic Carcinoma cell lines

Pancreatic Carcinoma Cell Lines

The following pancreatic cancer cell lines have been analysed by SKY. The linked pages show representative SKY karyotypes and some additional comment.

Pancreatic cancer cell Lines	ref		ref		ref
A818.1	[1]	Hs766T	[1]	Ro (Rossi)	[1]
AsPc-1	[1]	MIA PaCa-2	[1]	RWP-1	[1]
BxPC-3	[1]	MDA Panc-3	[1]	SUIT-2	[1]
Capan-1	[2, 3]	PaCa-3	[1]	SW-979	[1, 4]
Capan-2	[1]	PANC-1	[1]	T3M-4	[1]
CFPAC-1	[1]	PaTu I	[1]
Colo 357	[1]	PaTu II	[1]
FA6	[1]	QGP-1	[1]

References to the SKY data and comments

[1] Sirivatanauksorn V, Sirivatanauksorn Y, Gorman PA, Davidson JM, Sheer D, Moore PS, Scarpa A, Edwards PAW, Lemoine NR. Non-random chromosomal rearrangements in pancreatic cancer cell lines identified by spectral karyotyping. Int. J. Cancer 2001;91(3):350-358. PMID: 11169959

[2] Grigorova M, Staines JM, Ozdag H, Caldas C, Edwards PAW. Possible causes of chromosome instability: comparison of chromosomal abnormalities in cancer cell lines with mutations in BRCA1, BRCA2, CHK2 and BUB1. Cytogenet. Genome Res. 2004;104(1-4):333-340. PMID: 15162061

[3] BRCA2 mutant

[4] Has HPV so probably not genuine pancreatic tumour see Moore PS, Sipos B, Orlandini S, Sorio C, Real FX, Lemoine NR, Gress T, Bassi C, Kloppel G, Kalthoff H, Ungefroren H, Lohr M, Scarpa A. Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4. Virchows Arch. 2001;439(6):798-802. PMID: 11787853

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